[PDF][PDF] Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation
…, X Pan, X Yuan, L Zhou, L Yan, LH Zeng, J Xu, B Yang… - Cell reports, 2021 - cell.com
… of Plk1 but not Aurora B kinase activity. Taken together, … While 36 peptides of Bub1
were detected in control HeLa cells… -established role in promoting chromosome bi-orientation. …
were detected in control HeLa cells… -established role in promoting chromosome bi-orientation. …
Aurora B kinase: a potential drug target for cancer therapy
… expressions are common in various cell types, while Aurora C has been detected mostly
in … ABK wards off syntenic or merotelic connection with the centromere of chromosome in …
in … ABK wards off syntenic or merotelic connection with the centromere of chromosome in …
Mitotic R-loops direct Aurora B kinase to maintain centromeric cohesion
EC Moran, L Liu, E Zasadzinska, CA Kestner… - bioRxiv, 2021 - biorxiv.org
… Aurora B kinase associates with three other proteins to form the Chromosome Passenger
Complex (CPC). The CPC has a very dynamic localization during prophase; it is initially …
Complex (CPC). The CPC has a very dynamic localization during prophase; it is initially …
Chromosome oscillation promotes Aurora A–dependent Hec1 phosphorylation and mitotic fidelity
… ) and the error correction mechanism ensure bi-orientation … We also depleted Aurora B
using the AID system in RPE-1 … and merotelic attachments were also seen when Aurora B was …
using the AID system in RPE-1 … and merotelic attachments were also seen when Aurora B was …
[PDF][PDF] Investigating the Role of SUV4-20 Inhibition in Mitosis
S Brown - 2021 - digital.wpi.edu
… of Aurora B is independent of its methyltransferase activity. … merotelic and syntelic attachments.
When there is less tension … other binding partners of SUV4-20 that may regulate Aurora B, …
When there is less tension … other binding partners of SUV4-20 that may regulate Aurora B, …
[HTML][HTML] Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin
C Sacristan, K Samejima, LA Ruiz, M Deb… - Cell, 2024 - cell.com
… The CENP-A-enriched core centromere associates with the constitutive … , we detected a
$10-fold increase in the number of merotelic attachments when cells were treated with Aurora B …
$10-fold increase in the number of merotelic attachments when cells were treated with Aurora B …
[PDF][PDF] Overactive Aurora-A At Spindle Poles In Prometaphase Disrupts Mitotic Progression
E SILVESTRI - access.archive-ouverte.unige.ch
… Finally, a special thank you to my partner Emi. … They observed that Aurora B activity increased
in response to the … cell line model to study merotelic kinetochores than other human cell …
in response to the … cell line model to study merotelic kinetochores than other human cell …
[PDF][PDF] Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells
AM Gomes, B Orr, M Novais-Cruz, F De Sousa… - Current Biology, 2022 - cell.com
… merotelic kinetochore-microtubule attachments (when individual kinetochores bind to
microtubules oriented … Aurora B activity at centromeres of misaligned chromosomes.However, the …
microtubules oriented … Aurora B activity at centromeres of misaligned chromosomes.However, the …
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability
M Burigotto, V Vigorito, C Gliech, A Mattivi, S Ghetti… - EMBO …, 2023 - embopress.org
… identification of CENP-F as the kinetochore docking partner of … Moreover, merotelic
kinetochore-microtubule attachments … for the indicated kinase (AUR B = Aurora B). Bottom: dot …
kinetochore-microtubule attachments … for the indicated kinase (AUR B = Aurora B). Bottom: dot …
Effects of aneuploidy on cell behaviour and function
… correction mechanisms that involve the kinase Aurora B and other factors can convert syntelic
attachments and some merotelic … the overabundant proteins cannot find binding partners. …
attachments and some merotelic … the overabundant proteins cannot find binding partners. …