Microtubule depolymerization and severing during mitosis

D Schweizer - 2024 - studenttheses.uu.nl
… Kip3 associates with the microtubule lattice at a random … kinetochores are attached to the
same pole and III) merotelic, … Aurora B and its targets at the centromere and kinetochores

[PDF][PDF] Systematic Molecular Dissection Of Chromosome Congression In Human Cells Unveils A New Route For Micronuclei Formation

AMA Gomes - 2023 - repositorio-aberto.up.pt
kinetochores are oriented to the same spindle pole, and “… high Aurora B activity at the
kinetochores allow the correction of … of merotelic kinetochoremicrotubule attachments by assisting …

[HTML][HTML] Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes

J Dong, L Jin, S Bao, B Chen, Y Zeng, Y Luo, X Du… - Cell Discovery, 2023 - nature.com
… to correct erroneous K–MT attachments instead of aurora … Chromosomes that are bi-oriented
contain the most tension, … and ultimately leading to incorrect merotelic attachments 1,16 . …

Dissecting the Role of Polo Kinase in the Regulation of Kinetochore-Microtubule Attachments

JFPA de Barros - 2021 - search.proquest.com
… SPINDLY, an RZZc binding partner and KT adaptor for the … Restricting AURORA B activity
in the latter context may also … the same spindle pole – or merotelic – where a single KT …

Experimental and computational investigation of kinetochore protein dynamics

YN Ladak - 2020 - ora.ox.ac.uk
… analysing binding partners using DAPPER and its uniqueness are … to find the mean
mCherry-Aurora B cytoplasmic intensity for every … and correct a single merotelic attachment. A …

[HTML][HTML] Small but mighty: the causes and consequences of micronucleus rupture

M Kwon, ML Leibowitz, JH Lee - Experimental & molecular medicine, 2020 - nature.com
… fragments to their centric partners 39 (Fig. 2b, middle). The … B gaps colocalize with DNA
tethers coated with Aurora B and … were joined in random orientation and order and yielded only …

[PDF][PDF] Investigating the mitotic role of Retinoblastoma protein and its impact on chromosomal instability

A Stingi - access.archive-ouverte.unige.ch
… regulation is represented by its binding partner CyclinB, CyclinB is … bi-orientation and
correction of erroneous kinetochore-… Erroneous attachments like synthelic or merotelic may occur. …

Chromosome segregation fidelity is controlled by small changes in phospho-occupancy at the kinetochore-microtubule interface

TJ Kucharski, R Hards, KM Godek, SA Gerber… - BioRxiv, 2021 - biorxiv.org
… member and Hec1 binding partner Nuf2 (Figure S1B-F). … We next sought to compare how
the Aurora B and CDK1 … event related to the correction of an improperly oriented microtubule. …

[HTML][HTML] Hec1/Ndc80 tail domain function at the kinetochore-microtubule interface

RT Wimbish, JG DeLuca - Frontiers in cell and developmental biology, 2020 - frontiersin.org
… ; (3) Merotelic attachment: one sister kinetochore is attached to … labile, and Aurora B
kinase activity at kinetochores is high. … bi-orientation or Aurora B-mediated kinetochore-microtubule …

[HTML][HTML] The roles of transcription, chromatin organisation and chromosomal processes in holocentromere establishment and maintenance

Y Wang, L Wu, KWY Yuen - Seminars in Cell & Developmental Biology, 2022 - Elsevier
… It could be difficult to detect a neo-holocentromere on … These defects give rise to
merotelically oriented kinetochores, … roles of Aurora B is to correct aberrant kinetochore-microtubule …