… in demented patients. Such a reduction was not detected in Mild Cognitive Impairment
individuals… Clinical and cognitive changes occurring in AD patients have been associated with LC …

… changes and their association with cognitive function were explored in the SMC and MCI
groups. The purpose of this study was to explore the changes … detection of people at risk of AD. …

… locus coeruleus (LC) is a promising target for early diagnosis because of its early structural
alterations and its relationship to the functional disturbances in the patients. In … an increase of …

… was used to detect the changes of the locus coeruleus (LC) … 27 patients with AD, 15 patients
with mild cognitive impairment (… of locus coeruleus signal contrast ratios in the diagnosis of …

… We aimed to detect the extent of the LC signal attenuation in … that changes of the LC activity
may provide early detection … a biomarker for cognitive decline in AD patients. Future studies …

… Mild cognitive impairment (MCI) individuals had subjective … Locus coeruleus volume
and cell population changes during … biomarker discovery. Alzheimers Dement. 2017;13:236–46. …

… the early detection of AD-related cognitive decline and provide … participants and mild
cognitively impaired (MCI) patients. In … that these LC-network changes that we observed were …

… scans of the locus coeruleus, and subsets of individuals with a diagnosis of cognitively normal,
… adult general cognitive ability (GCA) so that MCI would reflect change from prior level of …

… to detect pathology-related changes in the noradrenergic system in vivo, several studies
compared patients … mutation carriers that show cognitive impairments based on the Washington …

… (LC) in the pathogenesis of Alzheimer's disease (AD) patients… a link between LC changes
and cognitive decline. Significant … the changes of the LC activity may provide early detection …