… the prodromal or mild cognitive impairment (MCI… changes can be used as a biomarker for
early AD detection. Indeed, if NA manipulation was to delay AD pathology, then early detection …

… 1524 cases who received a summary diagnosis at death of CU (n = 495), mild cognitive …
changes emerge decades before the first clinical symptoms (27), being able to detect and …

… in gauging locus coeruleus integrity and dysfunction at an … controlled trials and systematic
AD diagnosis. Thus, trials … suggest that the stage of mild cognitive impairment (MCI) may offer a …

… n = 10) amnestic mild cognitive impairment (aMCI) patients had a 30… of early diagnosis would
enable appropriate patient care. … (ADHD), which may overlap with cognitive changes in AD. …

… mild cognitive impairment and normal controls (NC), AD patients did not show functional
connectivity changes … In late-life major depressive disorder, overall target detection connectivity …

… cognitive decline when compared to patients with LOAD. In a recent retrospective review, it
was reported that up to two-thirds of patients … this work leading to the identification of at least 3 …

… , in PD patients suffering from mild cognitive impairment (PD-… Locus coeruleus volume
and cell population changes during … discovery. Alzheimers Dement. 2017;13(3):236–46. …

… of mild cognitive impairment and dementia; 23 patients with … LC contrast ratio undergoes
changes in various types of … The diagnosis of dementia due to Alzheimer's disease: …

… in mediating the changes from normal cognition (NC) to cognitive deterioration during AD. …
diagnosis of MCI or mild/moderate AD (MCI separated from AD; Table 1). The diagnosis of …

… of AD and hold promises for the identification of at-risk populations for preventive interventions.
… risk for cognitive decline as well as incident dementia [45], including but not limited to AD. …