Development of γδ T cells in the thymus–A human perspective
… T cells as well as the unconventional T cell … human [28], [29], [30], [31]. Nevertheless, we
will provide a brief overview of the earliest stages of T cell development in the human thymus. …
will provide a brief overview of the earliest stages of T cell development in the human thymus. …
The thymus medulla and its control of αβT cell development
… Classically, CD4 and CD8 are used to identify and study specific stages in T cell development
in the thymus. For example, immature T cell progenitors reside within the CD4 − CD8 − …
in the thymus. For example, immature T cell progenitors reside within the CD4 − CD8 − …
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
DG Pellicci, HF Koay, SP Berzins - Nature Reviews Immunology, 2020 - nature.com
… development is regulated. In this Review, we describe the thymic development of NKT cells,
MAIT cells and γδ T cells … between conventional and unconventional T cell development. …
MAIT cells and γδ T cells … between conventional and unconventional T cell development. …
Expansion of human γδ T cells in periphery: Lessons learned from development, infections, and compromised thymic function
S Ravens, E Tolosa - European Journal of Immunology, 2024 - Wiley Online Library
… Most of our understanding of γδ T-cell development, … allows now to decipher human γδ T-cell
biology in patient cohorts … , we summarize γδ T-cell development in the human thymus, their …
biology in patient cohorts … , we summarize γδ T-cell development in the human thymus, their …
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation
GJ Fiala, AQ Gomes, B Silva‐Santos - Immunological reviews, 2020 - Wiley Online Library
… γδ T cells develop alongside αβ T cells in the thymus, upon thymic egress most γδ T cells …
, where they can comprise up to 50% of all T cells. In the mouse, the tissue localization of γδ …
, where they can comprise up to 50% of all T cells. In the mouse, the tissue localization of γδ …
A cell atlas of human thymic development defines T cell repertoire formation
… We analyzed human thymic cells across development and postnatal life using scRNA-seq …
of thymic-derived T cells and the localization of cells constituting the thymus microenvironment…
of thymic-derived T cells and the localization of cells constituting the thymus microenvironment…
Regulation of γδ T cell effector diversification in the thymus
… γδ T cells are the first T cell lineage to develop in the thymus … αβ T cells that egress the
thymus as naïve cells, γδ T cells … function during development in the thymus. Understanding the …
thymus as naïve cells, γδ T cells … function during development in the thymus. Understanding the …
Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus
M Cordes, K Canté-Barrett, EB van den Akker… - Science …, 2022 - science.org
… We identified three thymus-seeding … the human thymus physiologically supports the
development of monocytes, dendritic cells, and NK cells, as well as limited development of B cells. …
development of monocytes, dendritic cells, and NK cells, as well as limited development of B cells. …
An integrated epigenomic and transcriptomic map of mouse and human αβ T cell development
… CD8 + T cell differentiation and a foundation for mechanistic investigations of αβ T cell
development. … αβ T cells develop in the thymus from precursors that express both CD4 and CD8 …
development. … αβ T cells develop in the thymus from precursors that express both CD4 and CD8 …
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
… We also provide an overview of major milestones in γδ T cell research since their discovery
… , development, fate decisions, and T cell receptor (TCR) rearrangement within the thymus. By …
… , development, fate decisions, and T cell receptor (TCR) rearrangement within the thymus. By …