Targeting angiogenic growth factors using therapeutic glycosaminoglycans on doppel-expressing endothelial cells for blocking angiogenic signaling in cancer

JU Choi, X Zhang, MM Hasan, M Karim, SW Chung… - Biomaterials, 2022 - Elsevier
… Heparin regulates angiogenesis, tumor growth and … of sprouting angiogenesis that form a
complex three-dimensional … the enhanced anti-angiogenic and tumor growth inhibitory effects: 1…

Molecularly imprinted nanomedicine for anti-angiogenic cancer therapy via blocking vascular endothelial growth factor signaling

M Zhao, P Guan, S Xu, H Lu, Z Liu - Nano letters, 2023 - ACS Publications
… Further, the anti-angiogenesis efficacy of anti-VEGF nanoMIP was studied. VEGF can stimulate
the proliferation of endothelial cells by interacting with VEGFR2. Therefore, the blockade …

[HTML][HTML] Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts

S Lee, H Kim, BS Kim, S Chae, S Jung, JS Lee… - Nature …, 2024 - nature.com
… Here, we apply an angiogenesis-on-a-chip to reconstruct 3D … -cell RNA sequencing of
sprouting endothelial cells from our … developing autophagy-based anti-angiogenic therapeutics. …

[HTML][HTML] Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance

X Yao, Y Zeng - Frontiers in Physiology, 2023 - frontiersin.org
… Therefore, angiogenesis has become a key target for cancer therapy, and several anti-angiogenic
drugs/inhibitors have been developed. … In a bio-3D printed in vitro vascular model of …

[HTML][HTML] Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy

JR van Beijnum, EJM Huijbers, K van Loon… - Nature …, 2022 - nature.com
… We report that tumor endothelial cells ubiquitously overexpress … to tumor-derived growth
factors, tumor endothelial cells (ECs) … by tumor ECs is a crucial player in tumor angiogenesis, …

Targeting of endothelial cells in brain tumours

W Duan, S Xia, M Tang, M Lin, W Liu… - … Translational Medicine, 2023 - Wiley Online Library
… to brain tumour development, providing … angiogenesis is the result of the interaction of
multiple TME components. Thus, targeting the TME may provide new ideas for the anti-angiogenic

[HTML][HTML] Recapitulating the angiogenic switch in a hydrogel-based 3D in vitro tumor-stroma model

C Kuehlbach, S Hensler, MM Mueller - Bioengineering, 2021 - mdpi.com
… To inhibit tumor growth by developing efficient anti-angiogenic … initiating angiogenesis is
essential. Yet so far, predominantly 2D … by endothelial cells and vessel associated cells, tumor

[HTML][HTML] Resistance mechanisms to anti-angiogenic therapies in cancer

Y Haibe, M Kreidieh, H El Hajj, I Khalifeh… - Frontiers in …, 2020 - frontiersin.org
Tumor angiogenesis relies on a highly complex program of growth factor signaling, endothelial
cell (EC) proliferation, extracellular matrix (ECM) remodeling, and stromal cell interactions

Emerging applications of anti-angiogenic nanomaterials in oncotherapy

B Tang, W Ma, Y Lin - Journal of Controlled Release, 2023 - Elsevier
Anti-angiogenic drugs target angiogenesis signaling … growth factor (bFGF) and prevent
the proliferation of human umbilical vein endothelial cells (HUVECs), showing an anti-angiogenic

[HTML][HTML] Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid

J Ekowati, KA Nofianti, MN Yunita… - Journal of Public …, 2023 - ncbi.nlm.nih.gov
… Anti angogenic activity was showed by endothelial cells growth … The energy minimization of
the 3D molecular structure was … endothelial cells, while one of the phases of angiogenesis is …