Targeting angiogenic growth factors using therapeutic glycosaminoglycans on doppel-expressing endothelial cells for blocking angiogenic signaling in cancer
… Heparin regulates angiogenesis, tumor growth and … of sprouting angiogenesis that form a
complex three-dimensional … the enhanced anti-angiogenic and tumor growth inhibitory effects: 1…
complex three-dimensional … the enhanced anti-angiogenic and tumor growth inhibitory effects: 1…
Molecularly imprinted nanomedicine for anti-angiogenic cancer therapy via blocking vascular endothelial growth factor signaling
M Zhao, P Guan, S Xu, H Lu, Z Liu - Nano letters, 2023 - ACS Publications
… Further, the anti-angiogenesis efficacy of anti-VEGF nanoMIP was studied. VEGF can stimulate
the proliferation of endothelial cells by interacting with VEGFR2. Therefore, the blockade …
the proliferation of endothelial cells by interacting with VEGFR2. Therefore, the blockade …
[HTML][HTML] Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts
… Here, we apply an angiogenesis-on-a-chip to reconstruct 3D … -cell RNA sequencing of
sprouting endothelial cells from our … developing autophagy-based anti-angiogenic therapeutics. …
sprouting endothelial cells from our … developing autophagy-based anti-angiogenic therapeutics. …
[HTML][HTML] Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
X Yao, Y Zeng - Frontiers in Physiology, 2023 - frontiersin.org
… Therefore, angiogenesis has become a key target for cancer therapy, and several anti-angiogenic
drugs/inhibitors have been developed. … In a bio-3D printed in vitro vascular model of …
drugs/inhibitors have been developed. … In a bio-3D printed in vitro vascular model of …
[HTML][HTML] Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
JR van Beijnum, EJM Huijbers, K van Loon… - Nature …, 2022 - nature.com
… We report that tumor endothelial cells ubiquitously overexpress … to tumor-derived growth
factors, tumor endothelial cells (ECs) … by tumor ECs is a crucial player in tumor angiogenesis, …
factors, tumor endothelial cells (ECs) … by tumor ECs is a crucial player in tumor angiogenesis, …
Targeting of endothelial cells in brain tumours
W Duan, S Xia, M Tang, M Lin, W Liu… - … Translational Medicine, 2023 - Wiley Online Library
… to brain tumour development, providing … angiogenesis is the result of the interaction of
multiple TME components. Thus, targeting the TME may provide new ideas for the anti-angiogenic …
multiple TME components. Thus, targeting the TME may provide new ideas for the anti-angiogenic …
[HTML][HTML] Recapitulating the angiogenic switch in a hydrogel-based 3D in vitro tumor-stroma model
C Kuehlbach, S Hensler, MM Mueller - Bioengineering, 2021 - mdpi.com
… To inhibit tumor growth by developing efficient anti-angiogenic … initiating angiogenesis is
essential. Yet so far, predominantly 2D … by endothelial cells and vessel associated cells, tumor …
essential. Yet so far, predominantly 2D … by endothelial cells and vessel associated cells, tumor …
[HTML][HTML] Resistance mechanisms to anti-angiogenic therapies in cancer
… Tumor angiogenesis relies on a highly complex program of growth factor signaling, endothelial
cell (EC) proliferation, extracellular matrix (ECM) remodeling, and stromal cell interactions…
cell (EC) proliferation, extracellular matrix (ECM) remodeling, and stromal cell interactions…
Emerging applications of anti-angiogenic nanomaterials in oncotherapy
B Tang, W Ma, Y Lin - Journal of Controlled Release, 2023 - Elsevier
… Anti-angiogenic drugs target angiogenesis signaling … growth factor (bFGF) and prevent
the proliferation of human umbilical vein endothelial cells (HUVECs), showing an anti-angiogenic …
the proliferation of human umbilical vein endothelial cells (HUVECs), showing an anti-angiogenic …
[HTML][HTML] Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid
… Anti angogenic activity was showed by endothelial cells growth … The energy minimization of
the 3D molecular structure was … endothelial cells, while one of the phases of angiogenesis is …
the 3D molecular structure was … endothelial cells, while one of the phases of angiogenesis is …