Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization

MR Nikmaneshi, RK Jain, LL Munn - PLoS Computational Biology, 2023 - journals.plos.org
anti-angiogenic and anti-cancer drugs can decrease cancermodel of tumor growth,
angiogenesis, metabolism and drug … the discrete agents, such as tumor and endothelial cells, with …

Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
… mechanisms and speculate how these processes may also be targeted with anti-angiogenic
Endothelial cells (ECs) are the pivotal cells in vascular development, lining the surface of all …

Cancer-associated angiogenesis: the endothelial cell as a checkpoint for immunological patrolling

AG Solimando, SD Summa, A Vacca, D Ribatti - Cancers, 2020 - mdpi.com
… of antiangiogenetic drugs is crucial to inhibit the growth of … of tumor immune surveillance by
its ability to interact directly … normalized cancer oxygen delivery after tailored anti-angiogenic

[HTML][HTML] … of αvβ3 integrin in 3D culture of triple-negative breast cancer and endothelial cells inhibits migration and discourages endothelial-to-mesenchymal plasticity

BC Casali, MP Baptista, BC Pachane, AA Cortez… - … and Biophysics Reports, 2024 - Elsevier
… of vascular endothelial growth factor (VEGF) overcoming … an initial step essential for
angiogenesis, we treated HUVEC … time the anti-angiogenic role of DisBa-01 in 3D cell culture, …

Microfluidics for angiogenesis research

L Costa, RL Reis, J Silva-Correia… - … Engineered 3D Models, 2020 - Springer
angiogenesis, such as the vascular endothelial growth … ) an endothelial cell culture channel,
allowing the simultaneous application of different concentrations of the anti-angiogenic drug

Angiogenesis and anti-angiogenic treatment in prostate cancer: mechanisms of action and molecular targets

E Ioannidou, M Moschetta, S Shah, JS Parker… - International journal of …, 2021 - mdpi.com
… trials, possibly leading to the development of new targeted anti-angiogenic therapies in PC.
… as tumor inhibitors [75]. They manage endothelial cellseffects and angiogenesis in PC …

KAI1 (CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state

JW Lee, J Hur, YW Kwon, CW Chae, JI Choi… - Journal of hematology & …, 2021 - Springer
… angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic
in suppressing metastasis and angiogenesis mainly in cancer cells and endothelial cells [4]. …

[HTML][HTML] Extracellular vesicles in tumor angiogenesis and resistance to antiangiogenic therapy

ZW Ye, ZL Yu, G Chen, J Jia - Cancer Science, 2023 - ncbi.nlm.nih.gov
… to endothelial cells (ECs) to promote tumor angiogenesis. … , several antiangiogenic drugs
have been developed and … Furthermore, VEGF 90k on the surface of EVs interacts well with …

[HTML][HTML] Tumor vessels as directors of the tumor microenvironment: new findings, current challenges & perspectives

L Treps, A Ager, K Hida - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
… the development of anti-angiogenic therapies, … tumor angiogenesis. Additionally, far from
being incapable of genetic plasticity (as initially suggested by Folkman) tumor endothelial cells

Validation of Human Bone Marrow-derived Mesenchymal Stem Cells and MCF-7 Breast Cancer Cells Co-culture Using a 3D Perfused Biomimetic Microfluidic …

AM Cimpean, S Comsa, A Sturza, AC Barb… - Anticancer …, 2024 - ar.iiarjournals.org
… platform for testing anti-tumor/anti-angiogenic drugs. … tumor growth through the process of
angiogenesis (9). The … to this experimental model, by replacing the endothelial cells with hBM-…