Current therapeutic interventions combating biofilm-related infections in orthopaedics: a systematic review of in vivo animal studies

J Li, WH Cheung, SK Chow, M Ip… - Bone & Joint …, 2022 - boneandjoint.org.uk
… To our knowledge, numerous studies have reported successful eradication of biofilm in …
study provides a novel rabbit model of infection following internal fixation with biofilm formation. …

Evaluation of biofilm colonization on multi-part dental implants in a rat model

E Blank, J Grischke, A Winkel, J Eberhard… - BMC Oral Health, 2021 - Springer
… during the removal of the abutments at the end of the experiment or disturbed biofilm
development on this relatively exposed surface throughout the experiment due to constant …

Development of an implantable three-dimensional model of a functional pathogenic multispecies biofilm to study infected wounds

C Cárdenas-Calderón, V Veloso-Giménez… - Scientific Reports, 2022 - nature.com
… of established multispecies biofilms that impair the … develop novel strategies for chronic
wound management. Thus, the aim of this work was to establish a biofilm-infected in vitro model, …

[HTML][HTML] Approaching prosthesis infection environment: Development of an innovative in vitro Staphylococcus aureus biofilm model

F Lamret, A Lemaire, M Lagoutte, J Varin-Simon… - Biofilm, 2023 - Elsevier
… However, its presence could strongly affect bacterial behaviour. Indeed, … Then, a prosthesis
as a foreign body may impair the bone … of an in vitro model of bone prosthesis infections. …

[HTML][HTML] Clinically relevant in vitro biofilm models: A need to mimic and recapitulate the host environment

HKN Vyas, B Xia, A Mai-Prochnow - Biofilm, 2022 - Elsevier
… To improve translatability, in vitro models must better recapitulate the host environment. This
… in vitro models that better mimic the environments of a variety of clinically important, biofilm-…

Biofilm-Infected human clusteroid three-dimensional coculture platform to replace animal models in testing antimicrobial nanotechnologies

A Wang, PJ Weldrick, LA Madden… - ACS Applied Materials & …, 2021 - ACS Publications
… , can impair wound healing, and potentially lead to sepsis. There has been a recent focus
on developing novel nanocarrier-based delivery vehicles to enhance the biofilm penetration of …

Human organoid biofilm model for assessing antibiofilm activity of novel agents

B Wu, EF Haney, N Akhoundsadegh… - npj Biofilms and …, 2021 - nature.com
biofilms cause 65% of all human infections and are highly … To provide a human organoid
model for studying host-… for novel antibiofilm agents, a human epidermis organoid model with …

Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

X Tan, X Cheng, M Hu, Y Zhang, A Jia, J Zhou, G Zhu - AMB Express, 2021 - Springer
… PAO1 was used as a model strain in this work to study biofilm developed in chronic wounds.
… used to culture the colonies in biofilms. LB medium was used for routine culture and growth. …

Current In Vitro Biofilm-Infected Chronic Wound Models for Developing New Treatment Possibilities

IC Thaarup, T Bjarnsholt - Advances in wound care, 2021 - liebertpub.com
… These factors should all be present in a good in vitro model, as they all have an impact
on the formed biofilm. This impact can be direct, such as when specific strains known to be …

Biofilm Formation by Pseudomonas aeruginosa in a Novel Septic Arthritis Model

D Li, L Zhang, J Liang, W Deng, Q Wei… - Frontiers in cellular and …, 2021 - frontiersin.org
study was to establish a rabbit model of septic arthritis caused by P. aeruginosa to determine
whether it leads to biofilm … (c-di-GMP) concentrations in biofilm formation in rabbit models. …