… drug screening strategy in the present study. The asterisk denotes exclusion process of frequent
hitters… with the potential to bind multiple target proteins were regarded as frequent hitters …

… We also review commonly used experimental detection techniques and computational
prediction … Development of a virtual screening method for identification of ‘frequent hitters’ in …

… for the evaluations of drug-likeness, frequent hitters, and toxicity are outlined. In addition,
the related Web servers and software packages developed recently for negative design are …

… Early in the development of HTS some compounds were noted to respond frequently 3 …
screen model section, we consider the binomial survivor approach to identifying frequent hitters, …

… growth of High-throughput screening (HTS) and combinatorial chemistry as cornerstones in
drug discovery,1, 2 virtual screening … found among the analyzed frequent hitters, which were …

… developed a reliable virtual screening process, combining different ligand- and structure–based
methods, to identify … them as “frequent hitters” in high-throughput screenings. Eventually, …

… Thus, the query molecules in virtual screening should be most representative of the wanted
… , which comprises compounds that appear as frequent hitters across multiple assays. Using …

… in a virtual screening approach against several targets. Positive results from the docking
approach can then be screened … to develop classifiers for the prediction of frequent hitters (also …

… developed to manipulate these chemical objects and associated bioactivity data. Virtual
screening methods … or unwanted promiscuous binders and frequent hitters). Other approaches …

… potential frequent hitters such as pan-assay interference compounds (PAINS) 108,109,110,111,112,113
among actives, given that these molecules may interfere with biological testing …