… that mice overexpressing protein targeting to glycogen (PTG) specifically in the liver—which
have increased glycogen … in the development of hepatic steatosis during DIO in mice [25]. …

… and ameliorated obesity and glucose tolerance. These effects … We crossed Akita mice with
animals overexpressing protein … /6-Ins2Akita/J) develop hyperglycemia at 3 weeks of age, and …

… of IRMOE mice and is likely responsible for increased glycogen … Our study shows that
overexpression of IR specifically in … glucose intolerance and development of diabetes in mice. This …

… processes of human diseases and to develop commonly … other animals [5], Albert Sabin
used monkeys to develop the … of antibiotics are tested on animals prior to trial in humans [8,9…

… development of gene therapy for the GSDs. The abnormal accumulation of glycogen and
deficiency of glucose … overexpression of secretable human GAA with an AAV vector in GSD IIIa …

… the major technical challenge toward the development of a single … glycogen reduction in
heart and muscle of Agl –/– mice 3 … Similarly, glycogen accumulation and histological features …

… on liver glucose-6-phosphate-deficient mice. … to develop possible treatments involving gene
therapy. Research performed using these models helped elucidate the role of glycogen and …

… the development of obesity and fatty liver diseases in males. … (C) The results of intraperitoneal
glucose tolerance test (IPGTT… (E) The glycogen content in liver tissues collected from 2–4 …

… to improved glucose tolerance and insulin sensitivity during … development and progression
[29], female fertility [30], tooth … glycogen depletion, while transgenic mice overexpressing …

… weight loss in obese mice. Unexpectedly, we observed that glycogen synthesis and degradation
are increased in response to catecholamines, and that glycogen turnover is required to …