Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases

L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
… -depleted animals, which displayed improved glucose tolerance … Apart from stimulating tumor
growth, increased glucose … The overexpression and positive effect of GSK3 on tumors have …

[PDF][PDF] Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis

R Klepochová, B Lair, M Lac, C Bergoglio… - researchgate.net
… Tissue glycogen levels were determined based on the formulation derived from the … mice
display systemic glucose intolerance, without apparently affecting muscle development and size…

Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice

LM de Souza Cordeiro, A Elsheikh, N Devisetty… - Diabetologia, 2021 - Springer
… in glucose homeostasis and may facilitate the development of new … glucose tolerance and
urine glucose levels in these mice. … We did not observe any differences in the hepatic glycogen

Overexpression of cardiac‐specific IGF‐IIRα accelerates the development of liver dysfunction through STZ‐induced diabetic hepatocyte damage in transgenic rats

CC Li, S Ramesh, TY Liu, TF Wang… - Environmental …, 2022 - Wiley Online Library
… Hypoinsulinemia and hyperglycemia were responsible for the decreased hepatic glycogen
glucose level in the oral glucose tolerance test; however, cardiac-specific overexpression of …

Gene Expression of in Type II Diabetics Compared to Non-Diabetics ()

SAH Khorami, MSA Mutalib, MF Shiraz… - The Open Diabetes …, 2020 - benthamopen.com
… Insulin-induced glycogen synthesis in elevated postprandial blood glucose levels … Transgenic
mice with muscle-specific overexpression of human GSK3 developed glucose intolerance

Characterizing the effects of muscle-specific GSK3a/b reduction on murine muscle contractility and metabolism in female mice

BL Hockey, MS Finch, JL Braun… - … of Physiology-Cell …, 2024 - journals.physiology.org
… The enzyme glycogen synthase kinase 3 (GSK3) is highly 40 … Glucose tolerance testing
(GTT) was performed after a 6 … kinase connections in insulin and growth-factor signalling. 443 …

An early, reversible cholesterolgenic etiology of diet-induced insulin resistance

JD Covert, BA Grice, MG Thornburg, M Kaur… - Molecular …, 2023 - Elsevier
… accumulation and glucose intolerance in male mice fed standard … confirmed that male and
female Tg mice develop insulin … in skeletal muscle glucose uptake and glycogen synthesis in …

Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: Lessons from animal models

AN Sferruzzi-Perri, J Lopez-Tello, T Napso, HEJ Yong - Placenta, 2020 - Elsevier
… to control litter genotype Glucose intolerant in late pregnancy due … Reduced glycogen content
and increased glucose … , but dams have a propensity to develop glucose intolerance and …

Hexokinase-2-linked glycolytic overload and unscheduled glycolysis—Driver of insulin resistance and development of vascular complications of diabetes

N Rabbani, M Xue, PJ Thornalley - International Journal of Molecular …, 2022 - mdpi.com
… on the glucose tolerance test are expected to develop at the … Transgenic mice overexpressing
HK2 in their skeletal muscle were … glycogen deposition in skeletal muscle in this transgenic

PPP1R3B is a metabolic switch that shifts hepatic energy storage from lipid to glycogen

KT Creasy, MB Mehta, J Park, CV Schneider… - bioRxiv, 2023 - biorxiv.org
overexpression and deletion in mouse and … mice develop glucose intolerance and steatosis
with aging or sucrose diet challenge, while Ppp1r3b OE mice have increased liver glycogen