Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives
X Cao, JP Coyle, R Xiong, Y Wang, RH Heflich… - In Vitro Cellular & …, 2021 - Springer
… Human airway has 23 generations of dichotomous branching… The ALI airway tissue models
discussed in this review are … , development of model systems for respiratory toxicology …
discussed in this review are … , development of model systems for respiratory toxicology …
Lung-on-a-chip: the future of respiratory disease models and pharmacological studies
J Shrestha, S Razavi Bazaz… - Critical reviews in …, 2020 - Taylor & Francis
… review is to describe and discuss current and future applications of lung-on-a-chip models
in the field of respiratory … [Citation58] developed a thermoplastic model of lung airway-on-a-…
in the field of respiratory … [Citation58] developed a thermoplastic model of lung airway-on-a-…
In vitro and in vivo development of the human airway at single-cell resolution
AJ Miller, Q Yu, M Czerwinski, YH Tsai, RF Conway… - Developmental cell, 2020 - cell.com
… To determine how similar induced organoids were to the native human fetal lung airway …
-derived airway or basal cell organoids and a single-cell atlas of the developing human airway …
-derived airway or basal cell organoids and a single-cell atlas of the developing human airway …
Human organs-on-chips for disease modelling, drug development and personalized medicine
DE Ingber - Nature Reviews Genetics, 2022 - nature.com
… Here, I review how single and multiple human organ chip systems have been used to model
… In addition, models of the asthmatic lung airway were developed by exposing healthy …
… In addition, models of the asthmatic lung airway were developed by exposing healthy …
Physiology and pathophysiology of human airway mucus
… , and strategies to develop these agents are reviewed. … available human data and data
from mouse models suggest … data describing the entire human respiratory tract, coupled to …
from mouse models suggest … data describing the entire human respiratory tract, coupled to …
The human respiratory system and its microbiome at a glimpse
… to the development of respiratory diseases, including allergies, asthma and others. In this
review, … , the larynx, the lower respiratory tract, and the gastrointestinal tract. The germs of the …
review, … , the larynx, the lower respiratory tract, and the gastrointestinal tract. The germs of the …
Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease
H Kiyokawa, M Morimoto - Development, Growth & …, 2020 - Wiley Online Library
… will review the roles of Notch signaling in lung development, … signaling in developing proximal
airways involves preserving … a mouse lung adenocarcinoma model markedly decreased …
airways involves preserving … a mouse lung adenocarcinoma model markedly decreased …
Is it time for reviewer 3 to request human organ chip experiments instead of animal validation studies?
DE Ingber - Advanced Science, 2020 - Wiley Online Library
… human Organ Chip models might better serve this purpose. This issue is addressed in this
article in context of the history of … infection model was developed using the Lung Airway Chip, …
article in context of the history of … infection model was developed using the Lung Airway Chip, …
[HTML][HTML] In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review
… vitro preclinical models have been recently developed and optimized to better resemble human
… In fact, the gastrointestinal tract (GIT) is one of the most active and dynamic organs in the …
… In fact, the gastrointestinal tract (GIT) is one of the most active and dynamic organs in the …
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
… develop primary human lung epithelial infection models to understand initial responses of
proximal and distal lung … Because the upper respiratory tract represents the most likely initial …
proximal and distal lung … Because the upper respiratory tract represents the most likely initial …