… immunofluorescent staining of pancreas tissue either at the time of diabetes diagnosis or
30 … necessary for tolerance induction (16). Two important considerations for the use of p:MHC-…

… pancreas-draining lymph nodes and islets in type 1 diabetes. … :R3-Treg treated mice maintain
normal beta cell function. … Tregs are primary cells from transgenic mice, whereas InsB:R3-…

… Autoimmune type 1 diabetes (T1D) is caused by T cell mediated destruction of … beta cells
of the islets of Langerhans in the pancreas. Regulatory T cells (Tregs), defined by expression of …

… -Foxp3-EGFP transgenic mice expressing GFP under the control of … B cells, erythrocytes,
and monocytes were depleted on an … of pancreatic antigen-specific amTregs in diabetic versus …

… B cells have been identified in the pancreas of mice that … Here, we present a novel proof
of concept that B cells can be … CD4 + T cells were isolated from BDC2.5 transgenic mouse …

… of pancreatic islet transplantation tolerance in diabetes, an … has proven useful for studies
of conditional beta cell loss and … mouse cells lack the DT receptor, cells in transgenic mouse …

… from the nonobese diabetic (NOD) mice presented peptide … to the autoimmune class II
MHC molecule (MHC-II) IA g7 and … We have documented that the MHC-II peptidome of B cells …

… complex, exert effector function and help B cells in … β cells from recent-onset type 1
diabetic donors express MHC … that pancreatic IFN-α upregulates the expression of MHC I …

… of insulin-producing pancreatic beta cells. As many as 1.25 … toward self-peptide–MHC
molecules to ensure a repertoire … switching and SHM in transgenic mice expressing either …

… In type 1 diabetes (T1D), the insulin-producing beta cells are … a transgenic mouse strain
derived from NOD mice 151. Thus, … autoreactive T cells target and kill their pancreatic beta cells. …