Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2-based chimeric antigen receptor
IA Radichev, J Yoon, DW Scott, K Griffin, AY Savinov - Cellular immunology, 2020 - Elsevier
… pathogenic, B cells can function as professional antigen presenting cells to stimulate T cells.
… of peripheral tolerance is the suppression of autoreactive T effector cells by Tregs. Thus, …
… of peripheral tolerance is the suppression of autoreactive T effector cells by Tregs. Thus, …
The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides
X Wan, AN Vomund, OJ Peterson, AV Chervonsky… - Nature …, 2020 - nature.com
… of the pancreatic islets in non-obese diabetic mice, which … We also examined the MHC-II
peptidome of CD19 + B cells … 10E11 TCR transgenic mice to HEL were generated in the …
peptidome of CD19 + B cells … 10E11 TCR transgenic mice to HEL were generated in the …
[HTML][HTML] Antigen-specific T cell responses in autoimmune diabetes
AJ Dwyer, ZR Shaheen, BT Fife - Frontiers in Immunology, 2024 - frontiersin.org
… replacing transgenic mice with DQ8 maintains islet reactivity and … from the pancreas of a
diabetic NOD mouse and caused … of diabetic NOD splenocytes with BCR-stimulated B cells to …
diabetic NOD mouse and caused … of diabetic NOD splenocytes with BCR-stimulated B cells to …
T-cell receptor/HLA humanized mice reveal reduced tolerance and increased immunogenicity of posttranslationally modified GAD65 epitope
Y Jing, Y Kong, J McGinty, G Blahnik-Fagan, T Lee… - Diabetes, 2022 - Am Diabetes Assoc
… , including expressing a single MHC class II molecule (H2-IA … spectrum of antigenic targets
in type 1 diabetes (13). To … cells accumulate in pancreatic islets and show a higher level …
in type 1 diabetes (13). To … cells accumulate in pancreatic islets and show a higher level …
Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetes.
HC Denroche, V Ng, J Velghe, I Suen, L Stanley… - bioRxiv, 2024 - biorxiv.org
… intact and beta cells from hIAPP transgenic mice did not … -mediated destruction of pancreatic
beta cells leading to … elicit islet inflammation and beta cell loss in type 2 diabetes. Islet …
beta cells leading to … elicit islet inflammation and beta cell loss in type 2 diabetes. Islet …
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes
N Pishesha, T Harmand, LY Smeding, W Ma… - Nature Biomedical …, 2021 - nature.com
… model of type I diabetes in the mouse and in a T cell-mediated … To test the possible involvement
of B cells, we administered … ) transgenic mice as a source of monoclonal CD4 + T cells …
of B cells, we administered … ) transgenic mice as a source of monoclonal CD4 + T cells …
[HTML][HTML] Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes
P Bhagchandani, CA Chang, W Zhao, L Ghila… - Scientific Reports, 2022 - nature.com
… Pancreatic islet β cells in these mice express the membrane-… Live single cells are gated
on CD19 to distinguish B cells, … -DTR mice for studies of immune tolerance, we transplanted …
on CD19 to distinguish B cells, … -DTR mice for studies of immune tolerance, we transplanted …
Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes
L Marroqui, AA Perez-Serna, I Babiloni-Chust… - … of Cell and Molecular …, 2021 - Elsevier
Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes - ScienceDirect
… Chapter One - Type I interferons as key players in pancreatic β-cell dysfunction in …
… Chapter One - Type I interferons as key players in pancreatic β-cell dysfunction in …
[HTML][HTML] Transcriptional re-programming of insulin B-chain epitope-specific T-follicular helper cells into anti-diabetogenic T-regulatory type-1 cells
P Solé, D Parras, J Yamanouchi, J Garnica… - Frontiers in …, 2023 - frontiersin.org
… and pancreatic lymph nodes of young pre-diabetic NOD mice … The second subset, ‘type B’,
exclusively targets a form of the … the secretory granules of pancreatic beta cells and is then …
exclusively targets a form of the … the secretory granules of pancreatic beta cells and is then …
Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice
S Tang, M Zhang, S Zeng, Y Huang… - Proceedings of the …, 2020 - National Acad Sciences
… of glucose during fasting ip glucose tolerance test (IPGTT), with … + β cells in the pancreatic
islets of firmly established diabetic … therapy of induction of MHC-mismatched mixed chimerism …
islets of firmly established diabetic … therapy of induction of MHC-mismatched mixed chimerism …