… As the expression of B7.1 in pancreatic β cells has been … HLA-DQ8 and HLA-DQ2 class II
MHC molecules, T1D patients were … observed in transgenic mice that co-expressed RIP-hB7.1 …

… of pancreatic islet beta cells by autoantigen-specific T cells, … TCR transgenic mice to make
antigen-specific cells. In … pancreatic islets expressing a mismatched MHC-I molecule, reduced …

… histocompatibility complex class II (MHCII) type 1 diabetes (… pancreatic beta cells within
a few weeks after birth (8). In H-… Studies in IA transgenic mice carrying chimeric IA alleles …

… of central and/or peripheral tolerance. Antigen-specific … with B cells), resulting in more
effective anergy induction (8). … pancreatic (PLN); pooled LNs had all, including pancreatic. …

… pre-diabetic, immunocompetent HLA-A2 + NOD mice may … T cells were rendered tolerant to
the endogenous pancreas … CD4 + T cells, CD8 + T cells and B cells all have pathogenic roles …

… expression on the transgenic mice beta cells, we also evaluated the glucokinase expression
in the pancreatic islet. … in a C57BL/6 transgenic mouse model of type 2 diabetes (T2D) [48]. …

… of the MHC molecule. The interaction between TCR/peptide/… of diabetes-resistant MHC
alleles in transgenic mouse … the eventual destruction of pancreatic beta cells. Evaluating this …

… Type 1 diabetes (T1D) is an autoimmune disorder characterised by destruction of the
insulin-producing beta cells within the pancreatic … Erythrocytes do not express MHC molecules …

… stimulated B cells (sBCs) for another 5 days and were thereafter injected in diabetic mice (2
x … HLA-A2 transgenic mouse islets into STZ-induced diabetic NSG mice, and then infused the …

… was investigated using an intraperitoneal glucose tolerance test using 2 g … cell-derived
beta cells in NOD mice expressing human HLA-A2 molecules instead of mouse MHC class I…