… clinical presentation, modern diagnosis, and management of functional heartburn. … diagnosis
of functional heartburn is commonly considered only in patients with persistent heartburn …

… with functional heartburn, symptoms result from esophageal hypersensitivity. A diagnosis of
… testing, whereas a diagnosis of functional heartburn also requires esophageal manometry. …

… Rome III separated patients with hypersensitive esophagus from NERD and recategorized
them under a new term of functional heartburn. Thus, patients were defined based on …

… reflux hypersensitivity, and functional heartburn with reflux as the … determinant at the other
end (functional heartburn).In summary, … (with the possible exception of functional heartburn), its …

… functional heartburn. Adjunctive metrics from pH-impedance monitoring, such as low distal
esophageal mean nocturnal baseline impedance (MNBI) or decreased postreflux swallow-…

… Functional heartburn is diagnosed when systematic workup reveals no esophageal endoscopic,
histologic, or motility abnormalities to account for heartburn, … negative SAP for heartburn. …

… reflux hypersensitivity, and functional heartburn. Patients with reflux symptoms despite normal
endoscopy remain common clinical presentation, can be heterogeneous overlapping with …

… of GERD, including pharmacologic, lifestyle, surgical, and endoscopic management. The
management of functional heartburn and other functional upper gastrointestinal (GI) symptoms …

… A significant proportion of patients with refractory GERD symptoms are diagnosed with reflux
hypersensitivity or functional heartburn following physiologic testing. Many of these patients …

… the functional heartburn group after complete testing [35, 36]. However, functional heartburn
is a … as functional dyspepsia or IBS where more specific therapy may be considered [37, 38]. …