Importance Colorectal cancer (CRC) is the third most common cause of cancer mortality
worldwide with more than 1.85 million cases and 850 000 deaths annually. Of new
colorectal cancer diagnoses, 20% of patients have metastatic disease at presentation and
another 25% who present with localized disease will later develop metastases.
Observations Colorectal cancer is the third most common cause of cancer mortality for men
and women in the United States, with 53 200 deaths projected in 2020. Among people …