Genistein prevents the production of hypospadias induced by Di-(2-ethylhexyl) phthalate through androgen signaling and antioxidant response in rats

B Shi, E He, K Chang, G Xu, Q Meng, H Xu… - Journal of Hazardous …, 2024 - Elsevier
… to human endogenous estrogens, are predominantly found in legume-based diets, … hormone
receptor binding, receptor expression regulation, steroid synthesis disruption, and hormone

[HTML][HTML] The use of soy isoflavones in the treatment of prostate cancer: a focus on the cellular effects

H Van der Eecken, S Joniau, C Berghen, K Rans… - Nutrients, 2023 - mdpi.com
… more affinity for estrogen receptor α (ER-α) [13,14]. Equol differs from genistein and daidzein
… confirmed an overall increase in survival after a boosted diet with genistein (250 mg/kgBW/…

[HTML][HTML] The role of isoflavones in the prevention of breast cancer and prostate cancer

T Pejčić, M Zeković, U Bumbaširević, M Kalaba, I Vovk… - Antioxidants, 2023 - mdpi.com
… via the androgen receptor (AR) and two estrogen receptors (… genistein/g food was reported
to significantly reduce prostate … impact of genistein on sex steroid receptor expression in rats

[HTML][HTML] Molecular changes underlying genistein treatment of wound healing: a review

M Čoma, V Lachová, P Mitrengová, P Gál - Current Issues in Molecular …, 2021 - mdpi.com
… Impact of gamma irradiation, a common food preserving … this context estrogen down-regulates
microRNA-7 expression … selective estrogen receptor agonists affect the expression pattern …

[HTML][HTML] Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Z Javed, K Khan, J Herrera-Bravo, S Naeem… - Cancer Cell …, 2021 - Springer
Genistein also targets estrogen receptor expression and suppresses the pathways … 1296
in prostate cancer cells. They have also found that exposure to genistein down-regulates MCM2 …

Therapeutic potentials of genistein: New insights and perspectives

S Rasheed, K Rehman, M Shahid… - Journal of Food …, 2022 - Wiley Online Library
… been conducted on rats by formulating the genistein-loaded … Genistein has a strong affinity
with human estrogen receptor … growth of prostate cancer when genistein and cholecalciferol …

Estrogen receptors-mediated health benefits of phytochemicals: A review

J Li, J Yu, H Zou, J Zhang, L Ren - Food & Function, 2023 - pubs.rsc.org
… , it increases the expression of ERβ in prostate cancer by … 6-hydroxydopamine hemi-Parkinsonian
rats, and the results of the … as genistein, can be used as natural dietary supplements for …

[HTML][HTML] Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer

NA Abd. Wahab, N H. Lajis, F Abas, I Othman, R Naidu - Nutrients, 2020 - mdpi.com
diet or dairy product-based calcium intake may elevate the risk of the disease [10]. Accordingly,
changes in diet … co-regulators, prostate intracrine androgen biosynthesis, modulation of …

[HTML][HTML] … for multilevel chemopreventive activities of natural phenols from functional genomic studies of curcumin, resveratrol, genistein, quercetin, and luteolin

L Huminiecki - International Journal of Molecular Sciences, 2022 - mdpi.com
… For example, miR-34a down-regulates the expression of … of miRNAs and lncRNAs in prostate
cancer cell lines. The … specimens were estrogen receptor positive (recall that genistein is …

Anticancer perspectives of genistein: a comprehensive review

H Naeem, U Momal, M Imran, M Shahbaz… - … Journal of Food …, 2023 - Taylor & Francis
… rise in both the capacity of genistein to rid rats of tumors and the … and genistein as potential
therapies for prostate cancer is the … of estrogen receptor alpha, the presence of genistein in …