Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways

J Wojnacki, G Quassollo, MD Bordenave… - Journal of cell …, 2024 - journals.biologists.com
… action restraining axon outgrowth … effect on axon development depending on when and
where exerts its action and the downstream effectors involved. In cultured hippocampal neurons, …

Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons

D Vallejo, CB Lindsay… - Journal of …, 2021 - Wiley Online Library
… in the regulation of Cofilin through Rac1 and Cdc42 in hippocampal neurons, we employed
selective inhibitors for each small Rho GTPase that directly target the GEF-binding domain (…

Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses

JG Duman, FA Blanco, CA Cronkite, Q Ru… - … GTPases, 2022 - Taylor & Francis
… flows from the axon of one neuron to the dendrite or cell … essential for dendritic growth arrest
in hippocampal neurons [… has different effects on the development of hippocampal circuits […

The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

T Kerloch, F Farrugia, L Bouit, M Maître, G Terral… - Molecular …, 2021 - nature.com
… late steps of dendritic growth and spine maturation in adult hippocampal newborn neurons
[17]. In … At the axon level, we did not observe any modification of the axon initial segment (AIS) …

The role of Rac GTPase in dendritic spine morphogenesis and memory

JF Costa, M Dines, R Lamprecht - Frontiers in synaptic neuroscience, 2020 - frontiersin.org
… For example, the normal distribution of filamentous actin (higher level of filamentous actin
in spines compared to the adjacent dendritic area) in hippocampal neurons, was disrupted in …

MMP-9 signaling pathways that engage rho GTPases in brain plasticity

I Figiel, PK Kruk, M Zaręba-Kozioł, P Rybak, M Bijata… - Cells, 2021 - mdpi.com
… in primary hippocampal neurons reduced the complexity of dendritic arbors, and this effect
was … NCAM plays a role in axonal and dendritic growth, synaptogenesis, and plasticity. It was …

Small GTPases of the Ras and Rho families switch on/off signaling pathways in neurodegenerative diseases

A Arrazola Sastre, M Luque Montoro… - International journal of …, 2020 - mdpi.com
dendritic spine formation in hippocampal primary neurons [24,… PD phenotype by inducing
axonal growth in DA neurons via Akt/… Furthermore, Rho GTPases are also implicated in other …

Semaphorin3F drives dendritic spine pruning through Rho-GTPase signaling

BW Duncan, V Mohan, SD Wade, Y Truong… - Molecular …, 2021 - Springer
… ligands that stimulate growth cone collapse and axon repulsion [8… analyzed Rho-GTPase
signaling in mouse cortical neuronhippocampal neuron cultures (Supplementary Table 1) [56]. …

Mechanisms of axon growth and regeneration: moving between development and disease

F Bradke - Journal of Neuroscience, 2022 - Soc Neuroscience
Differential distribution of acetylated and tyrosinated MTs in hippocampal neurons. A–H, …
unpolarized stage 2 (E–H) rat hippocampal neurons stained for acetylated (B, F) and …

Advances in understanding the molecular mechanisms of neuronal polarity

X Gu, C Jia, J Wang - Molecular Neurobiology, 2023 - Springer
… Shootin1 was found to interact with the retrograde flow of actin filaments and L1CAM in
the axonal growth cones of cultured rat hippocampal neurons, thus mediating the linkage …