[HTML][HTML] The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
… both during T cell priming and at the naive T cell stage has … on the formation of circulating T
cell subsets have shown that IL-… the T RM cells and the terminally differentiated T cell lineages…

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

JJ Milner, H Nguyen, K Omilusik… - Proceedings of the …, 2020 - National Acad Sciences
… roles of memory CD8 T cells in mice through delineation of a … -Tem subset within the human
circulating memory CD8 T cell … of CD127 hi CD62L lo Tem localized not only in the blood …

Area under immunosurveillance: Dedicated roles of memory CD8 T-cell subsets

L Parga-Vidal… - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
memory CD8 T-cell subsets that include Tcm, Tem, and Trm. Here, we will discuss how the
diversity in memory CD8 T cells arises duringmemory populations have shown differential

CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

N Prokhnevska, MA Cardenas, RM Valanparambil… - Immunity, 2023 - cell.com
… are primed in the secondary lymphoid organs that drain … the activated T cells from TDLNs
and the stem-like subset in the … to identify common and differential gene expression patterns in …

Motility matters: How CD8+ T-cell trafficking influences effector and memory cell differentiation

Y Farsakoglu, B McDonald… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
… to particular subsets of effector and memory CD8 + T cells, … CD8 + T cells acquire a terminally
differentiated effector state … Indeed, migration of Tcm cells into lymphoid organs is critical …

Tissue-specific differentiation of CD8+ resident memory T cells

K Yang, A Kallies - Trends in Immunology, 2021 - cell.com
Memory CD8 + T cells in mice and humans are phenotypically and functionally diverse and
comprise distinct subsets … range of non-lymphoid organs and are referred to as T RM cells. …

CD8+ T-cell memory: The why, the when, and the how

SJ Turner, TJ Bennett… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
subsets, memory T-cell populations may reflect different points on a spectrum between the
starting naive T-cell population and a terminally differentiated effector CD8 + … lymphoid organs

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

JT Crowl, M Heeg, A Ferry, JJ Milner, KD Omilusik… - Nature …, 2022 - nature.com
subsets of cells enriched for expression of effector- versus … TGF-β may shape T RM cell
gene expression during homeostasis, we … in T RM cell populations that included the differential

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

…, CE Widjaja, JN Kanbar, JG Olvera, T Tysl… - Science …, 2020 - science.org
… Moreover, we identify a distinct subset within the CD8 + T cell … rise to terminally differentiated
effector-like CD8 + T cells. In … populations within secondary lymphoid organs (74, 75). Our …

Spatial determinates of effector and memory CD8+ T cell fates*

BC Duckworth, RZ Qin, JR Groom - Immunological Reviews, 2022 - Wiley Online Library
… form terminally differentiated, short-lived effector cells (TWhile our study used T cell receptor
(TCR) transgenic CD8 + … Although multiple factors including antigen deposition, DC subsets