… In summary, descriptions of the soluble oligomeric forms of Aβ … The most bioactive Aβ
oligomers appear to be LMW, in … Fibril-containing plaques may be a major source of diffusible …

… soluble Aβ oligomers suggest that only certain bioactive forms (principally small, diffusible
oligomers… enhance clearance of existing oAβ) represents an attractive therapeutic strategy for …

… are given to soluble Aβ oligomers, due to their crucial roles in AD … with insoluble plaques,
soluble Aβ oligomers are highly … For AD, the deposition of Aβ plaques in brain represents the …

… of soluble oligomers and insoluble fibers of Aβ is an … soluble, small, diffusible forms of
Aβ are the most capable of binding to plasma membranes [23,24] and conferring bioactivity…

… the molecular pathology of Alzheimer’s Disease (AD). These … The toxic oligomers represent
a fraction of both the total Aβ … α–sheet containing toxic oligomers—critical early players in the …

… Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in …
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’…

… The highly toxic oligomers represent only a minority [43] of … Although the exact structure of
the highly bioactive AβO is not … , and rather the smaller, diffusible oligomers are involved in AD …

… As oligomers in human tissues can differ greatly in their size, … preclinical individuals is
crucial for this selection. As … also binds soluble amyloid precursor protein α-oligomers, such …

… point represents an average from three different Alzheimer's … elongated protofilaments and
toroidal oligomers per μm2 in … the former is affected very early in Alzheimer’s disease and the …

… an aqueous brain extract enriched in highly diffusible, bioactive forms of oAβ. Addition of …
the hypothesis that ‘fibrillar oligomers’ may exist in soluble extracts of Alzheimer’s disease brain …