… to related ansamycin scaffolds.The first total synthesis of an … illustrated that the hydroquinone
form of geldanamycin was as … for in vitro analysis; however, a low-micromolar affinity was …

… vivo instability limit the use of GM as an anticancer drug or diagnostic ligand in clinical trials.
As a member of the ansamycin … cells, we assessed the cellular binding affinity of [ 64 Cu]Cu-…

… take place in middle- or low-income countries. The leading … ring along with quinine-hydroquinone
and one of the rings … cisplatin) towards a wide range of cancer cell lines and in vivo …

… Geldanamycin (GA), a benzoquinone ansamycin compound … , such as low toxicity profiles
and increased in vivo activity and … differences between the 17-DMAG binding affinities for …

… They often display high-affinity binding, and are able to … conformations restrictions have
lower entropy loss when … fragments affect their antitumor activity in vitro, we also found that rings …

… Geldanamycin (GA), a benzoquinone ansamycin compound … , such as low toxicity profiles
and increased in vivo activity and … differences between the 17-DMAG binding affinities for …

… compounds that exhibit increased efficacy and potency toward … manifests T200Yfold higher
affinity for ATP than the … these heteroprotein complexes and their differential binding affinities. …

… was used for the oxidation of hydroquinone dimethyl ether (9) to … antioxidant action in AD
both in vitro [47] and in vivo [48] … Geldanamycin (16) was the first ansamycin antibiotic found in …

… GA was a first generation ansamycin analog with a … of 17-AAG, a highly soluble hydroquinone
hydrochloride IPI-504 (… While it exhibited similar antitumor activity as GA in vitro, in vivo …

… Cell sensitivity to ansamycin inhibitors of HSP90 was also … This could result from similar
affinity of quinone and hydroquinone … cell apoptosis and inhibit melanoma tumor growth in vivo […