… HTZ and HZ mice exhibited hippocampal impairment caused … that amyloid plaques are
deposited in the hippocampal … mouse models, such as 3xTg-AD, which exhibited changes …

… : APP and PS1 genes, a 3xTg-AD mouse model was generated to … ) failed to alter hippocampal
BDNF levels in mice, but this … Drugs, such as Latrepirdine (Dimebon), which was shown to …

… The major pathological changes in AD progression are the … before extracellular amyloid
deposition in five AD mice models [77… , but is activated in the hippocampus in AD patients. ErbB2 …

… LTP in the CA1 region of the hippocampus at 8 months of age. ...… to pathological changes in
the central nervous system (CNS) … pathology under progressing amyloid pathology in htau-KI …

… ageing due to the significant changes in the glutathione redox … to reveal that 3xTg-AD and
Tg-APP/PS1 mice were much less … containing Aβ42 in the mouse hippocampus, we used the …

… , RVT- 101), and latrepirdine (Dimebon) were evaluated as novel … eliminate amyloid plaques
in mice cortex and hippocampus … Berberine ameliorates β- amyloid pathology, gliosis, and …

… not detect any statistically significant changes on the levels of … plaques in the hippocampus
(p = 0.08) of running mice, in line … of Dimebon does not ameliorate amyloid-beta pathology in …

… 3xTg-AD model mice experienced a reduction in both Aβ and tangles in the hippocampus
and cortex… M1 mAChR’s significance to APP processing and amyloid pathology has also been …

… Similarly study on APP mice models of Alzheimer’s disease … of neurogenesis activity of
hippocampus, changes in insulin … the safety and effectiveness of Dimebon in mild to moderate …

… and amyloid-β accumulation. The disruption in calcium homeostasis accompanies changes
as observed in the whole brain pathology of … in hippocampal neurons of 3XTg-AD mice. The …