… , a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 …
… levels such as the type achieved by allosteric targeting of dopamine transporter activity. …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …
High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats
SE Swinford-Jackson, PJ Huffman… - …, 2023 - nature.com
… target region for examining the impact of DBS on cocaine seeking in preclinical models. DBS
of the shell subregion of the nucleus accumbens attenuated cocaine … of cocaine seeking [5], …
of the shell subregion of the nucleus accumbens attenuated cocaine … of cocaine seeking [5], …
Prescription psychostimulants for cocaine use disorder: A review from molecular basis to clinical approach
VS Tardelli, LF Berro, G Gerra, L Tadonio… - Addiction …, 2023 - Wiley Online Library
… target that mediates the abuse-related effects of cocaine, … MDPV-induced increases in
extracellular dopamine levels. … attenuates cocaine abuse behaviours by reducing its effects …
extracellular dopamine levels. … attenuates cocaine abuse behaviours by reducing its effects …
Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
M Xia, TL Anderson, ER Prantzalos… - …, 2024 - nature.com
… Behavioral effects were examined after NAc-targeted … We found no evidence that attenuation
of cocaine seeking by FC … on K v 7 control over extracellular dopamine levels or activity of …
of cocaine seeking by FC … on K v 7 control over extracellular dopamine levels or activity of …
Substance Addiction Rehabilitation Drugs
S Yuan, SC Jiang, ZW Zhang, ZL Li, J Hu - Pharmaceuticals, 2024 - mdpi.com
… -activating effects of cocaine and attenuated the substance-… receptors (D3Rs) have attracted
much attention as targets for … pallidum drives extracellular dopamine accumulation in the …
much attention as targets for … pallidum drives extracellular dopamine accumulation in the …
Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum
M González-Portilla, S Mellado… - Behavioral and Brain …, 2023 - Springer
… effects on cocaine-related behavior OEA may be targeting … was to evaluate the effects of
OEA on cocaine reward by using … to the changing extracellular dopamine concentrations and …
OEA on cocaine reward by using … to the changing extracellular dopamine concentrations and …
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens
CD Teague, EJ Nestler - Molecular psychiatry, 2022 - nature.com
… have opposite effects on transcription at different target genes … intracellular signaling pathways
that contribute to cocaine-… κ opioid receptors (KORs) and attenuates DA neuron firing. This …
that contribute to cocaine-… κ opioid receptors (KORs) and attenuates DA neuron firing. This …
Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation
PM Estave, SE Albertson, AN Karkhanis, SR Jones - Scientific Reports, 2024 - nature.com
… 2) reduced effects of cocaine on extracellular DA … attenuating subjective or reinforcing
effects of cocaine 59 , it is possible that phendimetrazine may be successful as part of a dual-target …
effects of cocaine 59 , it is possible that phendimetrazine may be successful as part of a dual-target …
Motivated Arousal in Anticipation of Cocaine Access: Maladaptive Actions of Corticotropin Releasing Factor on the Accumbens Dopamine Signal
MZ Leonard - 2022 - search.proquest.com
… CRF to modify extracellular DA qualitatively differed in drug-experienced … attenuates
responding in anticipation of cocaine-availability……………………….….…157 Figure 24. No effects …
responding in anticipation of cocaine-availability……………………….….…157 Figure 24. No effects …
Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder
R Chen, MJ Ferris, S Wang - Pharmacology & therapeutics, 2020 - Elsevier
… an array of membrane and intracellular proteins to tightly control … applying drug combinations
to target multiple components of … The ability of cocaine and AMPH to increase midbrain DA …
to target multiple components of … The ability of cocaine and AMPH to increase midbrain DA …