Pyrrolidine in drug discovery: a versatile scaffold for novel biologically active compounds

G Li Petri, MV Raimondi, V Spanò, R Holl… - Topics in Current …, 2021 - Springer
… In this review, we report bioactive molecules with target selectivity characterized by the … this
review, we highlight the interest of the chemistry community in pyrrolidine and its derivatives, …

Synthesis and in silico studies of some new pyrrolidine derivatives and their biological evaluation for analgesic and anti-inflammatory activity

AK Mishra, K Anjali, H Singh, A Mishra… - Annales Pharmaceutiques …, 2023 - Elsevier
… models, all newly synthesized pyrrolidine derivatives were profiled using the COX1 and
COX2 inhibition assay. The newly synthesized compounds were discovered to have responses …

Design, synthesis, and biological evaluation of 4-phenoxybenzenesulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

J Mao, H Zhang, X Wang, J Gao, J Tang… - BioScience Trends, 2020 - jstage.jst.go.jp
discover many potent and orally activepyrrolidine derivatives (9), sulfonyl pyrrolidine
derivatives (10), quinoxalinone peptidomimetic derivatives (11), ProGly peptidomimetic derivatives (…

An Overview on Biological Importance of Pyrrolone and Pyrrolidinone Derivatives as Promising Scaffolds

M Asif, S Alghamdi - Russian Journal of Organic Chemistry, 2021 - Springer
… to synthesize various pyrrolone and pyrrolidinone derivatives. Numerous methods for the
synthesis of … , and ketone moieties as in talaroconvolutin A is the prime instance discovered in …

Synthesis and biological evaluation of pyrazoline and pyrrolidine‐2, 5‐dione hybrids as potential antitumor agents

K Tilekar, N Upadhyay, FJ Meyer‐Almes… - …, 2020 - Wiley Online Library
… In search of novel and effective antitumor agents, pyrazoline‐substituted pyrrolidine‐2,5‐dione
hybrids were designed, synthesized and evaluated in silico, in vitro and in vivo for …

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors

D Si, H Luo, X Zhang, K Yang, H Wen, W Li, J Liu - Bioorganic Chemistry, 2021 - Elsevier
… MDM2, a hit unsaturated pyrrolidone scaffold was obtained through virtual screening. Several
unsaturated pyrrolidone derivatives were synthesized and biological evaluated. As a result…

Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities

KM Attalah, AN Abdalla, A Aslam, M Ahmed… - Bioorganic …, 2020 - Elsevier
… pyrrolizine and indolizine moieties 8–11 were synthesized and evaluated for their anti-inflammatory
and anticancer activities. Among these derivatives, compounds 9a, 10b and 11b …

[PDF][PDF] An Overview on Biological Importance of Pyrrolone and Pyrrolidinone Derivatives as Promising Scaffolds

M Asifa, S Alghamdib - Russian Journal of Organic Chemistry, 2021 - researchgate.net
… to synthesize various pyrrolone and pyrrolidinone derivatives. Numerous methods for the
synthesis of … , and ketone moieties as in talaroconvolutin A is the prime instance discovered in …

Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors

E Park, SJ Lee, H Moon, J Park, H Jeon… - Journal of Medicinal …, 2021 - ACS Publications
… the synthesis of various methyl amide derivatives provided 4-((cis-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
(31g) as a potent …

Synthetic access to syn-functionalised chiral hydroxy pyrrolidines and pyrrolidones: Evaluation of α-glucosidase inhibition activity, docking studies and …

SN Mhaldar, GD Kotkar, SG Tilve - Bioorganic Chemistry, 2022 - Elsevier
… In consideration to this, academic researchers are actively indulged in synthesizing novel
pyrrolidine iminosugars which have proved to be potent α-glucosidase inhibitors in …