[HTML][HTML] Development of folate receptor− targeted pet radiopharmaceuticals for tumor imaging—a bench-to-bedside journey
SD Boss, SM Ametamey - Cancers, 2020 - mdpi.com
… either chemotherapeutics for therapeutic or prosthetic groups for imaging purposes have been
… Almost all folic acid-based chemotherapeutic drugs and radiopharmaceuticals have been …
… Almost all folic acid-based chemotherapeutic drugs and radiopharmaceuticals have been …
[HTML][HTML] The concept of folic acid in health and disease
Y Shulpekova, V Nechaev, S Kardasheva, A Sedova… - Molecules, 2021 - mdpi.com
… The discovery of folic acid is the result of hard work of Lucy Wills, a medical researcher
graduating from Cambridge University with the degree of botanist and geologist. In 1930, she …
graduating from Cambridge University with the degree of botanist and geologist. In 1930, she …
Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances
… -targeted delivery, which proved significant targeting efficacy. As a result of this strategy,
various folic acid-based small … properties weren't discovered until the middle of the 20th century. …
various folic acid-based small … properties weren't discovered until the middle of the 20th century. …
Advancements in folate receptor targeting for anti-cancer therapy: A small molecule-drug conjugate approach
A Rana, S Bhatnagar - Bioorganic chemistry, 2021 - Elsevier
… We also discuss the criteria for selecting the optimal therapeutic drug payload, spacer and
… Finally, we review the folate receptor targeting SMDCs that are in preclinical development …
… Finally, we review the folate receptor targeting SMDCs that are in preclinical development …
Synthesis and Characterization of Folic Acid-Conjugated Terbium Complexes as Luminescent Probes for Targeting Folate Receptor-Expressing Cells
GT McMullon, A Ezdoglian, AC Booth… - Journal of Medicinal …, 2024 - ACS Publications
… Because of this, there is a great need to develop imaging agents … development of a
personalized treatment approach. Macrophages play a crucial orchestrating role in the development …
personalized treatment approach. Macrophages play a crucial orchestrating role in the development …
[HTML][HTML] Can nuclear imaging of activated macrophages with folic acid-based radiotracers serve as a prognostic means to identify COVID-19 patients at risk?
Herein, we discuss the potential role of folic acid-based radiopharmaceuticals for
macrophage imaging to support clinical decision-making in patients with COVID-19. Activated …
macrophage imaging to support clinical decision-making in patients with COVID-19. Activated …
[HTML][HTML] Single-versus dual-targeted nanoparticles with folic acid and biotin for anticancer drug delivery
M Jurczyk, K Jelonek, M Musiał-Kulik, A Beberok… - Pharmaceutics, 2021 - mdpi.com
… of cell-surface protein receptor targets, the endogenous receptors are manually … the
therapeutic ligand (quality); and (4) dual-targeting systems that characterize simultaneous targeting …
therapeutic ligand (quality); and (4) dual-targeting systems that characterize simultaneous targeting …
Identification of a PET radiotracer for imaging of the folate receptor-α: a potential tool to select patients for targeted tumor therapy
P Guzik, HY Fang, LM Deberle… - Journal of Nuclear …, 2021 - Soc Nuclear Med
… The use of folic acid–based radiotracers for nuclear imaging … patients who would profit from
FR-targeted tumor therapies (7–10). … Discovery and development of folic-acid-based receptor …
FR-targeted tumor therapies (7–10). … Discovery and development of folic-acid-based receptor …
[PDF][PDF] Chemotherapeutic applications of folate prodrugs: A review
YF Mustafa - NeuroQuantology, 2021 - researchgate.net
… in the drug design and discovery stages have been developed during the last several …
treatment effectiveness, and this method has resulted to the development of many folic acid–based …
treatment effectiveness, and this method has resulted to the development of many folic acid–based …
[HTML][HTML] Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates—new perspectives for folate receptor–targeted radionuclide therapy
P Guzik, M Benešová, M Ratz… - … and molecular imaging, 2021 - Springer
… and, hence, an interesting target for radionuclide therapy. The aim of this study … a targeting
agent and to compare their properties with those of the previously established folic acid-based …
agent and to compare their properties with those of the previously established folic acid-based …