… in AR-positive (AR+) breast cancer. We have recently reported the discovery of a highly potent
PROTAC AR degrader, … Using metribolone (R1881), a highly potent AR agonist, we further …

… to the discovery of ARD-2051 as a highly potent and orally … previously employed AR ligand
6 for the design of a highly potent … that AR degradation induced by ARD-2051 is effectively …

… A series of PROTAC AR degraders were synthesized using … that A031 was a potent AR
degrader. The tumor growth … design of highly potent and efficient PROTAC AR degraders. …

… bioavailable PROTAC AR degraders, we decided to employ cereblon ligands. … fairly potent
and effective AR degrader and compound 13 is a highly potent and very effective AR degrader…

… of the androgen receptor (AR). ARD-1676 was designed … of potent and orally bioavailable
PROTAC AR degraders using a … is a highly potent and effective AR degrader but is slightly less …

… the discovery of highly potent PROTAC degraders of androgen … AR degraders is critical for
the potent and effective reduction of … These general strategies employed in our study provide …

… improvement of degradation activity following employment of … are highly potent and effective
in reducing AR-FL and AR-V7 … potent PROTACs led to the identification of the most effective …

… chimeras (PROTAC) was … using several different classes of AR antagonists and a von
Hippel−Lindau (VHL) ligand [9]. The most potent one exhibited excellent degradation potency …

… recruiting cereblon, we were able to demonstrate the potent … [ 33 ] For our PROTAC design,
we contemplated CRBN as the most … the hypothesis that AR inhibition or degradation may not …

… potent and potentially safe androgen receptor (AR) degrader, … of highly potent and effective
AR degraders are needed more … PROTAC conjugates are currently in progress in our group. …