… the discovery of CP subtypes, the interest in selective CP … the peptide substrate Ac-PAL-AMC,
used to selectively monitor … Furthermore, PR-924 and its derivatives show high selectivity …

… immunoproteasome-selective inhibitors with electrophilic groups at the C-terminal of the
peptide … important approach for the discovery of novel immunoproteasome-selective inhibitors. …

… discovery of 7-chloro-substituted benzoXazole-2-carbonitriles that inhibited the β5i subunit
of iCP in the low micromolar range, showed preferential inhibition … -peptide inhibitors against …

… β2c, and β5c with the immunoproteasome subunits low molecular mass polypeptide (LMP) 2
(… for longer time periods, whereas PRN1126 remained highly selective for LMP7 and did not …

… Reversible linear and cyclical peptide inhibitors that lack electrophiles have also been … and
immunoproteasomes were elucidated by X-ray diffraction. They are highly selective over β1c …

… of the constitutive proteasome and immunoproteasome with comparable potency, which …
discovery and structure-based hit optimization of novel amido boronic acids, which selectively …

… DPLG3 is a highly selective immunoproteasome β5i inhibitor with single-… inhibition of only
β5i or β5c can induce cell death is still understudied; (2) selective inhibition of β5i by peptide …

… 1), a highly selective and potent β5i non-covalent inhibitor, … The aforementioned observations
suggested that selective inhibition of … Most known i-20S inhibitors are featured by a peptide …

… , we herein report the discovery of a series of selective β5i inhibitors through fragment-based …
P3 site were the most selective inhibitors, which showed higher selectivity than ONX-0914. …

… of various peptide-based iCP selective inhibitors (see … of the Immunoproteasome Low
Molecular Mass Polypeptide … with a highly selective immunoproteasome inhibitor promotes …