Dissolution behavior and thermodynamic properties of apixaban in pure and mixed solvents
C Du, Y Cong, Y Zhang, Y Xue, B Qiao, T Ye… - The Journal of Chemical …, 2020 - Elsevier
The solubility profile of apixaban in pure and mixed solvents within the temperature range
from (288.15 to 328.15) K under atmosphere pressure (101.3 kPa) was studied and
evaluated by some thermodynamics models. The solid state of apixaban in equilibrated form
was characterized using powder X-ray diffraction (PXRD) technique. The maximum mole
solubility in pure solvents was obtained in 1, 4-dioxane (3.648× 10− 3) at 328.15 K, and
followed by methanol (1.967× 10− 3), acetone (7.885× 10− 4), ethanol (6.049× 10− 4) …
from (288.15 to 328.15) K under atmosphere pressure (101.3 kPa) was studied and
evaluated by some thermodynamics models. The solid state of apixaban in equilibrated form
was characterized using powder X-ray diffraction (PXRD) technique. The maximum mole
solubility in pure solvents was obtained in 1, 4-dioxane (3.648× 10− 3) at 328.15 K, and
followed by methanol (1.967× 10− 3), acetone (7.885× 10− 4), ethanol (6.049× 10− 4) …
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