… They demonstrated unique structure of Pannexin 1 channel in comparison with other various
eukaryotic channels. Furthermore, they revealed that the central large pore is covered with …

… Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-… altered the banding profile and
subcellular distribution of both … The diversity in ub chains created by adjusting chain linkage, …

… at least two distinct open conformations with different permeabilities. When activated by high
… In contrast, it has been inferred that when opened in physiological settings by various stimuli…

Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of physiological
functions such as blood pressure regulation 1 , apoptotic cell clearance 2 and human …

… its diverse activation modes, association with diverse signaling molecules and broad cellular
and tissue distribution 2 . … 8i, we show convergence of our PMF profiles over 8 ns. Each ion …

… How Pannexin-1 senses and integrates such diverse stimuli to form an open and closed …
subtype has a unique binding profile, activation profile, subcellular localization and G protein …

… of molecular diversity amongst the … under different physiological settings. This thesis explores
the biophysical gating mechanisms of Panx1 by undergoing a targeted mutational profile of …

… been shown to contribute to different modes of cell death (ie, … of inflammatory disease
involving various organs, including … their different gating properties along with different molecular …

… radius distribution, overall pore profiles and electrostatic properties [44,47], but PANX3 has
a highly varied … These channels may have diverse functions and selectivity in a homomeric …

… different stimuli and combinations thereof cause Panx1 to adopt different conformations with
different … , distinct binding sites and that different inhibitors may cause Panx1 to adopt a fully …