… the same genetic variant with various phenotypic expressions… Clinical studies of gene networks,
however, are theoretical, … in many different forms and at hundreds of targets converge on …

… common genetic variants associated with schizophrenia have … used type of gene network
analysis is weighted gene co-… that causal genes should converge in tight functionally related …

… and ASD may share certain genetic variants with discordant effects, … variations at 22q11.2
produce distinct and convergent … An integrative gene network-based approach to uncover the …

… , many individuals with schizophrenia endure poor societal functioning, stigma and a poor
… and rare genetic variants that implicate various biological pathways in schizophrenia. We …

… Genes are known to display high variation in expression … of genes related to psychiatric
conditions may affect different … -state functional networks (Figure 4A), disorder risk genes indeed …

… expressed in different brain cell types and neurons, as well … the functional analyses across
common and rare variants, the … ultra-)rare variant gene-set and cell type enrichment analyses …

… points of convergence among these genes with diverse biological … fold enrichment for rare
inherited variants). This study reported 102 … associated with ASD, NDD, schizophrenia (SCZ), …

… expression at the level of individual genes, gene network analysis identified two cortical and
… To address whether specific genetic variants imparting major risk for SCZ or ASD converge …

… Gaining insight into the mechanistic influences of these genetic variants … and rare genetic
variants, as well as diverse environmental … with specific classes of loss-of-function variants [27]. …

… of polygenicity is that genomic variants converge on a limited … of the activity in different
brain regions during rest (14, 15). … brain mechanisms involved in schizophrenia and autism. …