Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
… the convergence of putative schizophrenia risk genes in brain … Interindividual genetic
variation associated with risk-… of coexpressed genes from SNPs varied across different modules, …
variation associated with risk-… of coexpressed genes from SNPs varied across different modules, …
Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosis
Q Li, X Xu, Y Qian, H Cai, W Zhao, J Zhu, Y Yu - Schizophrenia, 2023 - nature.com
… brain functional measures involved ReHo, ALFF, and CBF, we used various combinations of
… GWAS have indicated that genetic variations associated with the calcium signaling pathway …
… GWAS have indicated that genetic variations associated with the calcium signaling pathway …
The shared genetic basis of mood instability and psychiatric disorders: A cross‐trait genome‐wide association analysis
… genes with an apparent convergence on synaptic gene-sets, … that a large proportion of
genetic variants are not unique for … multiple mental phenotypes to different degrees. As such, the …
genetic variants are not unique for … multiple mental phenotypes to different degrees. As such, the …
[HTML][HTML] Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia
… among genetic variants, coordinated regulatory activity and gene expression. To … gene [20],
and on the convergence of deviations detected in different molecular layers as seen for gene …
and on the convergence of deviations detected in different molecular layers as seen for gene …
[HTML][HTML] Boosting schizophrenia genetics by utilizing genetic overlap with brain morphology
D Van der Meer, AA Shadrin, K O'Connell, F Bettella… - Biological …, 2022 - Elsevier
… genetic variants contributing to brain-linked schizophrenia risk… different GWASs to predict
schizophrenia and intelligence. … in these findings through converging evidence. Further …
schizophrenia and intelligence. … in these findings through converging evidence. Further …
Contextualizing Convergent
MJ Gandal - Exploring and Exploiting Genetic Risk for Psychiatric …, 2023 - books.google.com
… In schizophrenia (SCZ) and autism spectrum disorder (ASD), … networks captured the same
processes as gene networks … tiple classes of genetic variation (SNPs, CNVs, and rare variants) …
processes as gene networks … tiple classes of genetic variation (SNPs, CNVs, and rare variants) …
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
… to predict effects of genetic variations on DNAm levels in the … regulatory variants are not
confounded by LD, are convergent … with our previous knowledge about schizophrenia genetics …
confounded by LD, are convergent … with our previous knowledge about schizophrenia genetics …
Genetic association of FMRP targets with psychiatric disorders
… FMRP binding and genetic association with schizophrenia, major … find that across multiple
types of genetic variant and multiple … Consistent with genetic observations, a convergence on …
types of genetic variant and multiple … Consistent with genetic observations, a convergence on …
An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
CY Zhang, X Xiao, Z Zhang, Z Hu, M Li - Molecular Psychiatry, 2022 - nature.com
… different protein networks [105]. Adding more complexity to the functional impact of alternative
splicing in schizophrenia, … to uncover the functional complexity of these diverse alternative …
splicing in schizophrenia, … to uncover the functional complexity of these diverse alternative …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
… autoencoders to infer gene networks from expression data, … used in this study from diverse
ancestries (210 individuals of … appropriate to reinforce stimuli converging on striatal neurons. …
ancestries (210 individuals of … appropriate to reinforce stimuli converging on striatal neurons. …