[HTML][HTML] … review of the human accelerated regions in Schizophrenia and related disorders: where the evolutionary and neurodevelopmental hypotheses converge
M Guardiola-Ripoll, M Fatjó-Vilas - International Journal of Molecular …, 2023 - mdpi.com
… placement of different mental disorders—such as schizophrenia, … genetic variability of HAR
brain genes affected the functional … , in contrast to the results in other functional networks [66]. …
brain genes affected the functional … , in contrast to the results in other functional networks [66]. …
Investigating trait variability of gene co-expression network architecture in brain by manipulating genomic signatures of schizophrenia risk
… the patterns of its manifestations are varied and complex. To … of genetic variants potentially
accounting for phenotypic … , indicate consistency and functional convergence of the genomic …
accounting for phenotypic … , indicate consistency and functional convergence of the genomic …
[HTML][HTML] Expansion of schizophrenia gene network knowledge using machine learning selected signals from dorsolateral prefrontal cortex and amygdala RNA-seq …
… We found that two different brain loci (DLPFC … of gene networks between the two major
functional regions of the brain in SCZ. To control confounding effects from population differences, …
functional regions of the brain in SCZ. To control confounding effects from population differences, …
[HTML][HTML] The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research
T Nakamura, A Takata - Molecular Psychiatry, 2023 - nature.com
… by considering all analyzable common genetic variants … various allele frequencies and effect
sizes of genetic variants … we can obtain convergent insight into the pathological changes in …
sizes of genetic variants … we can obtain convergent insight into the pathological changes in …
Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene
JY Wang, XY Li, HJ Li, JW Liu, YG Yao, M Li… - Schizophrenia …, 2021 - academic.oup.com
… provides convergent lines of evidence for the involvement of … outside and differentiate
into different types of neural cells and … that genetic variants may confer schizophrenia risk by …
into different types of neural cells and … that genetic variants may confer schizophrenia risk by …
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
Schizophrenia Working Group of the Psychiatric … - MedRxiv, 2020 - medrxiv.org
… diversity of synaptic proteins identified in this study suggests multiple functional interactions
of schizophrenia risk converging … to identify specific genetic variants with horizontal pleiotropy…
of schizophrenia risk converging … to identify specific genetic variants with horizontal pleiotropy…
[PDF][PDF] Revisiting antipsychotic drug actions through gene networks associated with schizophrenia
SB Rosenthal, M Jiang, R Abagyan - academia.edu
… other and converge on related biological and functional networks, … Genetic variations in
CYP2D6, a gene linked to drug … in different brain areas has been linked to the different aspects of …
CYP2D6, a gene linked to drug … in different brain areas has been linked to the different aspects of …
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
… risk 5 , development and aging, and local genetic variation in … We found 406 genes with
significantly different expression … We note that the TWAS algorithm forces both the convergence …
significantly different expression … We note that the TWAS algorithm forces both the convergence …
Rethinking the first episode of schizophrenia: identifying convergent mechanisms during development and moving toward prediction
JK Forsyth, CE Bearden - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
… which genetic variants associated with schizophrenia increase risk… to maximize psychosis
prediction under different contexts. … and functional brain changes in first episode psychosis and …
prediction under different contexts. … and functional brain changes in first episode psychosis and …
[HTML][HTML] Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders
… 2 are among the genetic variants most strongly associated with … for ASD additionally converge
on networks involved in early … loading highly onto gene networks that orchestrate neuronal …
on networks involved in early … loading highly onto gene networks that orchestrate neuronal …