… is a frequently used therapeutic option for patients with MGD when mechanical treatment
modalities are not sufficient to reach … are poorly lipophilic and therefore do not reach high tissue …

… oral administration of doxycycline results in detectable tear film concentrations in dogs
reaching … Oral doxycycline administration only achieves a tear concentration of 0.43 μg/mL 9 to …

… tear film. Moreover, the topical azithromycin group seemed to be superior over the oral
doxycycline group in improving the quality of tear film … could not reach the therapeutic level on the …

… TBUT and meibomian gland expression compared to systemic doxycycline (Group B) (p<…
to systemic doxycycline. The localized action and superior outcomes in tear film stability and …

… RCES with oral doxycycline in our series had a much lower efficacy than what is reported
in … Does orally administered doxycycline reach the tear film? Br J Ophthalmol. 2008;92(6):856-…

… doxycycline is mediated by a large number of mechanisms. The anti-inflammatory effects of
doxycycline … The same effect could not be achieved with the oral administration of doxycycline…

… tear film pharmacokinetics following topical administration of … of an eye drop that reaches
the systemic circulation in dogs. … oral administration of prednisone (0.5–4.0 mg/kg) (18), tear …

… doxycycline is mediated by a large number of mechanisms. The anti-inflammatory effects of
doxycycline … The same effect could not be achieved with the oral administration of doxycycline…

… of the tear film. The deplet- ed meibum results in increased … at day 8 and reached quicker
inflammatory relief than AZM … third compared the clinical effects of oral doxycycline (DOX) to …

… but not doxycycline was quantifiable in tear film of cats receiving the same oral dose (5 mg/…
In conclusion, ceftiofur administered subcutaneously at 5 mg/kg reached the tear fluid of dogs …