Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease
… explore the role of Parkin in mitigating α-synuclein induced toxicity … treatment largely prevented
all the cytotoxic effects of iron (Figure … In a recent study we showed that dopamine (DA) or …
all the cytotoxic effects of iron (Figure … In a recent study we showed that dopamine (DA) or …
The role of α-synuclein in methamphetamine-induced neurotoxicity
M Wu, H Su, M Zhao - Neurotoxicity Research, 2021 - Springer
… mechanisms that are involved in METH-induced neurotoxicity and the significance of …
propose that α-synuclein may also affect dopamine homeostasis and subsequent cytotoxic events …
propose that α-synuclein may also affect dopamine homeostasis and subsequent cytotoxic events …
N-acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase
R El-Habta, S af Bjerkén, A Virel - Neurological Research, 2024 - Taylor & Francis
… this study, SH-SY5Y cells differentiated towards a dopaminergic … 5 mM were cytotoxic to
human SH-SY5Y cells and significantly … Statistical significance was calculated using one-way …
human SH-SY5Y cells and significantly … Statistical significance was calculated using one-way …
[HTML][HTML] Ellagic acid prevents α-synuclein aggregation and protects sh-sy5y cells from aggregated α-synuclein-induced toxicity via suppression of apoptosis and …
… The present study aimed to assess the role of Ellagic acid (EA), … -syn, we treated dopaminergic
neuroblastoma SH-SY5Y cells with … (C) The cytotoxicity of aged α-syn in SH-SY5Y human …
neuroblastoma SH-SY5Y cells with … (C) The cytotoxicity of aged α-syn in SH-SY5Y human …
β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson's Disease
M Xian, J Li, T Liu, K Hou, L Sun… - ACS Chemical …, 2024 - ACS Publications
… loss of dopaminergic neurons in vitro, highlighting α-Syn’s role in … cytotoxicity, contributing
to the onset or progression of PD. … (79) SH-SY5Y cells treated with 25 μM paraquat exhibited …
to the onset or progression of PD. … (79) SH-SY5Y cells treated with 25 μM paraquat exhibited …
… SH-SY5Y human neuroblastoma cells against 6-hydroxydopamine-induced cytotoxicity by ameliorating dopamine biosynthesis and dopamine receptor D2 gene …
KB Magalingam, SD Somanath, S Md… - Nutrition Research, 2022 - Elsevier
… level is directly or indirectly affected by TH and α-synuclein … Considering the role of T3 isoforms
and TRF on α-synuclein … patients on dopamine agonist [44], suggesting the importance of …
and TRF on α-synuclein … patients on dopamine agonist [44], suggesting the importance of …
… attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein
J Zhong, M Li, J Xu, W Dong, Y Qin, S Qiu, X Li… - Toxicology and applied …, 2022 - Elsevier
… significance and will promote the discovery of novel therapeutic targets for the intervention
… Our study suggests a potential therapeutic strategy for the intervention of dopaminergic …
… Our study suggests a potential therapeutic strategy for the intervention of dopaminergic …
[HTML][HTML] Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol
S Aoki, T Funakoshi, T Aki, K Uemura - Toxicology reports, 2022 - Elsevier
… SH-SY5Y human dopaminergic neuronal cells stably … the cytotoxicity of METH on SH-SY5Y
neuroblastoma cells, … on the importance of cholesterol homeostasis in protecting cells against …
neuroblastoma cells, … on the importance of cholesterol homeostasis in protecting cells against …
Role of alpha-synuclein phosphorylation at Serine 129 in methamphetamine-induced neurotoxicity in vitro and in vivo
J Ding, Y Wang, J Huang, Y Lian, Y Meng, C Li… - …, 2020 - journals.lww.com
… important role in METH-induced neurotoxicity in dopaminergic … We tested the PLK2 level
in SH-SY5Y cells after METH … genes, and assessed the cytotoxicity from apoptosis levels and …
in SH-SY5Y cells after METH … genes, and assessed the cytotoxicity from apoptosis levels and …
[HTML][HTML] Copper dependent modulation of α-synuclein phosphorylation in differentiated Shsy5y neuroblastoma cells
M Greco, CC Spinelli, L De Riccardis… - International Journal of …, 2021 - mdpi.com
… of oxidative stress and the cytotoxic effect of copper compared to … role of copper and all
mechanisms correlated to α-synuclein … -like cells to reproduce some of the dopaminergic neuron …
mechanisms correlated to α-synuclein … -like cells to reproduce some of the dopaminergic neuron …