… β-Lactam/β-Lactamase Inhibitor Use in Hospital-Acquired and Ventilator-Associated Pseudomonas aeruginosa Pneumonia for Patients Who Are Morbidly Obese

AJ Kunz Coyne, C Orzol, MP Veve… - Open Forum Infectious …, 2023 - academic.oup.com
… for morbid obesity used in the current study (BMI ≥35 mg/kg … BL/BLI dosing in patients who
are morbidly obese and have P … –based dosing coupled with modified dosing administrations …

Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase (ESBL)-producing versus non-ESBL-producing Escherichia coli in a …

K Islam, FB Sime, MJ Bauer, BM Forde… - International Journal of …, 2022 - Elsevier
… activity of piperacillin/tazobactam (TZP) dosing regimens … , and piperacillin/tazobactam
(TZP) could play a role in this context and may reduce selection pressure. Piperacillin/tazobactam

Piperacillin/Tazobactam in critically ill morbidly obese patients: A case series: The first One‐Centre experience with TDM

M Mieresova, K Balazova, J Kubele… - Clinical Case …, 2023 - Wiley Online Library
… /TAZO in critically ill obese patients immediately after the first administered dose. In the context
of … maximization of PIP/TAZO dose at baseline to rapidly saturate increased V d in obese

An integral pharmacokinetic analysis of piperacillin and tazobactam in plasma and urine in critically ill patients

E Wallenburg, R Ter Heine, JA Schouten… - Clinical …, 2022 - Springer
piperacillintazobactam therapy ≤ 72 h before inclusion, and were managed with a central
venous and/or arterial catheter. PatientsDose and duration of piperacillintazobactam were …

… Target Attainment of Continuous Infusion PiperacillinTazobactam or Meropenem and Microbiological Outcome among Urologic Patients with Documented Gram …

PM Berrino, M Gatti, M Rinaldi, E Brunocilla, P Viale… - Antibiotics, 2023 - mdpi.com
… In patients performing more than one TDM-guided ECPA for piperacillintazobactam
dosing … (the first one before any dosage adjustment and the subsequent ones after eventual …

Pharmacodynamic evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum β-lactamase-producing and non-producing Escherichia coli …

K Islam, FB Sime, SC Wallis, MJ Bauer… - Journal of …, 2022 - academic.oup.com
dosing in HFIM, piperacillin/tazobactam and meropenem stock solutions were prepared from
piperacillin/tazobactam (… ) and meropenem (Meropenem, 1000 mg, Fresenius Kabi Pty Ltd, …

Pharmacodynamics of piperacillin-tazobactam/amikacin combination versus meropenem against extended-spectrum β-lactamase-producing Escherichia coli in a …

K Islam, FB Sime, SC Wallis, MJ Bauer… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
… For example, in the presence of 8/8 mg/L piperacillin-tazobactam, the GRM copy number
per cell increased approximately 10-fold to >90, which reflects at least an ~800-kb increase in …

β-lactam therapeutic drug monitoring in critically ill patients: weighing the challenges and opportunities to assess clinical value

TJ Dilworth, LT Schulz, ST Micek, MH Kollef… - Critical care …, 2022 - journals.lww.com
… -based dose optimisation of piperacillin/tazobactam to improve outcome in patients with
sepsis (… on CRRT, and those on ECMO and/or morbid obesity. Prospective studies focusing on …

Population pharmacokinetics of piperacillin in non-critically ill patients with bacteremia caused by enterobacteriaceae

V Merino-Bohórquez, F Docobo-Pérez… - Antibiotics, 2021 - mdpi.com
Patients were included only if: the first piperacillintazobactam dose was administered in the
… of the therapy was at least 48 h, and the patient was not admitted to the intensive care unit. …

[PDF][PDF] Vancomycin and Linezolid dosing in Obese and Overweight Patients: Is There a Universally Accepted Dosing Protocol to Improve their Efficacy?

W Yusuf, M Sagir, IA Ahmed, MS Ladan… - Malaysian Journal of …, 2022 - researchgate.net
… for morbidly obese individuals. The peculiar interactions of several antibiotics are affected by
morbid obesity (… in normal renal functioning morbidly obese patients were developed. It was …