The harsh microenvironment in early breast cancer selects for a Warburg phenotype

M Damaghi, J West… - Proceedings of the …, 2021 - National Acad Sciences
… to emerge from DCIS selection is the Warburg Effect (WE) phenotype, which is defined as …
known driver gene mutations. This suggests that there may be mutation-independent drivers of …

Pathogens hijack host cell metabolism: intracellular infection as a driver of the Warburg effect in cancer and other chronic inflammatory conditions

AD Proal, MB VanElzakker - Immunometabolism, 2021 - journals.lww.com
… In order to activate and respond to the infection, the cells would additionally adapt a Warburg
phenotype, since a Warburg metabolism drives the essential increase in ATP production …

Revisiting the Warburg effect: historical dogma versus current understanding

P Vaupel, G Multhoff - The Journal of physiology, 2021 - Wiley Online Library
Warburg effect, ie aerobic glycolysis in the presence of oxygen and – in principle – functioning
mitochondria, constitutes a major driver … The Warburg phenotype constitutes a metabolic …

Lactate and lactate transporters as key players in the maintenance of the Warburg effect

A Pereira-Nunes, J Afonso, S Granja… - … : the main driver of …, 2020 - Springer
… The Warburg metabolic phenotype proved to be a useful tool not only for clinical detection
of glucose-addicted tumours, but also to monitor tumour growth and dissemination by 18 F-…

Warburg and pasteur phenotypes modulate cancer behavior and therapy

C Karaca, A Tokatli, A Tokatli, A Karadag… - Anti-cancer …, 2022 - journals.lww.com
… Rate-limiting glycolytic enzymes and glucose transportation appears as favored therapeutic
targets to reverse the Warburg phenotype. One such enzyme, hexokinase II (HK-2) drives

'Warburg effect'controls tumor growth, bacterial, viral infections and immunity–Genetic deconstruction and therapeutic perspectives

J Pouysségur, I Marchiq, SK Parks, J Durivault… - Seminars in cancer …, 2022 - Elsevier
… These findings demonstrate that LDHA plays a key role in maintaining a Warburg phenotype
in cancer cells, by promoting tumorigenic potential of malignancies, thus making LDHA a …

RETRACTED CHAPTER: The Warburg Effect: Historical Dogma Versus Current Rationale

P Vaupel, G Multhoff - Oxygen Transport to Tissue XLII, 2021 - Springer
… The Warburg effect reflects a metabolic program of cancer cells driving sustained … 27.2
Schematic illustration of biochemical steps of the Warburg phenotype. Upon enhanced import …

Revisiting the Warburg effect with focus on lactate

E Kocianova, V Piatrikova, T Golias - Cancers, 2022 - mdpi.com
… as one of the drivers of tumor growth. As a result, aerobic glycolysis, or the Warburg effect,
is a … an invasive phenotype and the formation of metastases—a further consequence of the …

The Warburg effect: a signature of mitochondrial overload

Y Wang, GJ Patti - Trends in cell biology, 2023 - cell.com
… mitochondria, a phenomenon known as the ‘Warburg effect.' An abundance of evidence
shows … As such, the Warburg effect becomes a signature of excess glucose being released as …

The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells

M Jaworska, J Szczudło, A Pietrzyk, J Shah… - Pharmacological …, 2023 - Springer
… (Warburg effect) in cancer cells. However, it should be noted that hypoxia itself may also lead
to the selection of cells with the Warburg phenotype (… acquiring the Warburg phenotype by …