… acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs). … inactivation and mitigates
dronedarone-induced cardiac AEs. … dronedarone-induced cardiac mitochondrial dysfunctions …

… Mitochondrial dysfunction has been reported to occur in the … , calcium ions and a significant
reduction in the levels of … induced-apoptosis to dronedarone-induced cytotoxicity, with the …

… -dependent reduction in mitochondrial oxygen consumption of … in the heart, as demonstrated
here in human platelets. … its metabolite (DEA) elicits platelet mitochondrial dysfunction. …

… Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction… In line, in our experiments, we have seen a reduction …

… reason for dronedarone-induced arrhythmia [… it is of great significance to study the relationship
between drug-induced cardiotoxicity and mitochondrial damage caused by the reduction …

… , such as mitochondrial toxicity, might mitigate the occurrence of unexpected cardiotoxicity. …
Since arrhythmia and mitochondrial dysfunction exist as two distinct entities in cardiotoxicity, …

… CYPs participate in a vast array of processes ranging from oxidation/reduction of foreign …
the heart. CYP2J2 was found to mediate olefin epoxidation of AA into epoxyeicosatrienoic acids …

… cardiomyocytes and the reduction of myocardial systolic function, … myocardial mitochondrial
dysfunction and poor cardiac remodeling, ultimately developing cardiac systolic dysfunction […

… rescued the DOX-induced reduction in left ventricular ejection … YWPC could alleviate
mitochondrial dysfunction and cause … epoxyeicosatrienoic acids have beneficial effects in heart …

… epoxyeicosatrienoic acids by ibrutinib and osimertinib serves as a novel mechanism for
TKI-induced cardiac … The inhibition of both drugs on cardiac AA metabolism could be clinically …