… The cerebellar pilocytic astrocytomas classically show a cyst … described is a duplication at
chromosome 7q34 whereby the … as specific in confirming a diagnosis of pilocytic astrocytoma …

… of cortical neurogenesis, and midbrain and cerebellum development. Alterations in this
pathway … This duplication at 7q34 is practically specific for pilocytic astrocytomas as it is rare or …

… astrocytomas (PAs), the most common CNS tumor in children, 1 are most commonly located
in the cerebellum … Cerebellar PAs are associated with a higher rate of gross-total resection (…

… A radiological hallmark of this disease is widespread … , Sylvian fissures, brainstem and
cerebellar folia. Discrete parenchymal … loss and 7q34 gain associated with both classes, but more …

… This is distinct from pediatric PA where cerebellar and cerebral/lobar … duplication of
chromosome 7q34 was reported as a frequent chromosomal abnormality in PA. The 7q34 …

… The biphasic pattern is best seen in cerebellar tumours. … an approximately 2 Mb duplication
of 7q34, encompassing the … with a histological hallmark of a specific glioneuronal element …

… for these diagnostically relevant hallmark genomic changes. … in the cerebellum and represent
the most common glioma … majority show a tandem duplication at 7q34 involving gain of …

… of pLGG and their hallmark molecular alterations are listed in … identified focal gains at 7q34
which included the BRAF gene [… and in tumors arising in the posterior fossa/cerebellum (Fig. 3…

… associations with the cerebellum. While this chapter (Part I) will discuss pilocytic astrocytoma,
… The most common genetic alteration found in PAs is the tandem duplication at 7q34, which …

… PA is most commonly located in the posterior fossa, specifically in cerebellar hemispheres.
… The most common genetic alteration is the BRAF internal tandem duplication resulting with a …