The Physiological Functions of Beta-defensin 19/119 in the Male Reproductive Tract

J Jin - 2021 - search.proquest.com
development of germ cells and the microbiome of the MRT. … to investigate the dynamics
of microbiota or changes in its … showed that β-defensin DEFB119 specifically expressed in …

Crucial convolution: Genetic and molecular mechanisms of coiling during epididymis formation and development in embryogenesis

J Wong, J Gasperoni, J Fuller, SVH Grommen… - Journal of …, 2022 - mdpi.com
SPAG11C is an androgen-regulated β-defensin required for Wolffian duct coiling, however,
epithelial AR signalling has been shown to be non-essential for coiling. WNT signalling has …

β-Defensins: Antimicrobial Peptides at the Intersection of Immunity and Male Fertility

V Batra, A Kumaresan, R Kumar, TK Datta - Current Concepts in Bovine …, 2022 - Springer
… BD gene expression in the MRT in a Spatio-temporal manner (… expression levels of BDs like
Spag11a (Bin1b) and Spag11c … genome controls the expression of β-defensin genes would …

An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

SH Leir, S Yin, JL Kerschner, W Cosme… - Life science …, 2020 - life-science-alliance.org
… The B form of SPAG11 contains a C-terminal β-defensin domain which is lacking from the A
… gene expression signature than those in cluster 0: although other members of the β defensin

Epididymal embryonic development harbors TLR4/NFKB signaling pathway as a morphogenetic player

LGA Ferreira, FA Nishino, SG Fernandes… - Journal of Reproductive …, 2022 - Elsevier
… (coiled duct) WDs, and spatio-temporal changes in TLR4 … We have shown that β-defensin
SPAG11C (sperm associated … that regulates both the dynamic remodeling of ECM components…

Busulfan administration replicated the characteristics of the epididymal initial segment observed in mice lacking testis-epididymis lumicrine signaling

D Kiyozumi - Journal of Reproduction and Development, 2024 - jstage.jst.go.jp
… A heatmap representation of the fold changes in gene expression in IS-caput of the … Dynamic
changes in the spatio-temporal expression of the β-defensin SPAG11C in the developing