DNA methylation in mammalian development and disease

ZD Smith, S Hetzel, A Meissner - Nature Reviews Genetics, 2024 - nature.com
… Here, we summarize the current understanding of the distinct DNA methylation landscapes
that emerge over the mammalian lifespan and discuss how they interact with other regulatory

Role of mammalian DNA methyltransferases in development

Z Chen, Y Zhang - Annual review of biochemistry, 2020 - annualreviews.org
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development… understanding of the regulation of DNA methylation dynamics in mammalian germ …

A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development

Y Yang, X Fan, J Yan, M Chen, M Zhu… - Nucleic acids …, 2021 - academic.oup.com
… of gene expression and plays a critical role in mammalian development. However, the
dynamic regulation of genome-wide DNA methylation in skeletal muscle development remains …

[HTML][HTML] Spatiotemporal DNA methylome dynamics of the developing mouse fetus

Y He, M Hariharan, DU Gorkin, DE Dickel, C Luo… - Nature, 2020 - nature.com
DNA methylation is essential for mammalian development but understanding of its spatiotemporal
distribution in the developing embryo … Here, as part of the mouse Encyclopedia of DNA

Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

N Petryk, S Bultmann, T Bartke… - Nucleic acids …, 2021 - academic.oup.com
… the mechanisms, dynamics and fidelity of DNA methylation maintenance in mammals. We
also discuss how it could be regulated in normal development and misregulated in disease. …

[HTML][HTML] Dynamics of DNA methylation and its functions in plant growth and development

S Kumar, T Mohapatra - Frontiers in Plant Science, 2021 - frontiersin.org
regulation of growth, development, … dynamics of DNA methylation (cytosine/adenine) in
plants, its functions in regulating gene expression under abiotic/biotic stresses, developmental

Active turnover of DNA methylation during cell fate decisions

A Parry, S Rulands, W Reik - Nature Reviews Genetics, 2021 - nature.com
… In the current Perspective, we discuss recent findings that describe this intriguing phenomenon
and the potential importance of this process during early mammalian development and …

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development

KT Falcon, KEN Watt, S Dash, R Zhao… - Proceedings of the …, 2022 - National Acad Sciences
… Altogether, our results demonstrate a dynamic spatiotemporal requirement for rRNA
transcription during mammalian cranial NCC development and corresponding tissue-specific …

[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics

S Li, Y Peng, AR Panchenko - Current opinion in structural biology, 2022 - Elsevier
DNA methylation plays a vital role in epigenetic regulation in both plants and animals,
and typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …

Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development

R Yan, X Cheng, C Gu, Y Xu, X Long, J Zhai, F Sun… - Nature Genetics, 2023 - nature.com
… to aberrant DNA demethylation at developmental essential genes such as Lefty1/2, which
resulted in inactivation of Lefty expression 32 . We thus examined the DNA methylation level at