DNA methylation in mammalian development and disease
ZD Smith, S Hetzel, A Meissner - Nature Reviews Genetics, 2024 - nature.com
… Here, we summarize the current understanding of the distinct DNA methylation landscapes
that emerge over the mammalian lifespan and discuss how they interact with other regulatory …
that emerge over the mammalian lifespan and discuss how they interact with other regulatory …
Role of mammalian DNA methyltransferases in development
… DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development… understanding of the regulation of DNA methylation dynamics in mammalian germ …
development… understanding of the regulation of DNA methylation dynamics in mammalian germ …
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
Y Yang, X Fan, J Yan, M Chen, M Zhu… - Nucleic acids …, 2021 - academic.oup.com
… of gene expression and plays a critical role in mammalian development. However, the
dynamic regulation of genome-wide DNA methylation in skeletal muscle development remains …
dynamic regulation of genome-wide DNA methylation in skeletal muscle development remains …
[HTML][HTML] Spatiotemporal DNA methylome dynamics of the developing mouse fetus
… DNA methylation is essential for mammalian development but understanding of its spatiotemporal
distribution in the developing embryo … Here, as part of the mouse Encyclopedia of DNA …
distribution in the developing embryo … Here, as part of the mouse Encyclopedia of DNA …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
… the mechanisms, dynamics and fidelity of DNA methylation maintenance in mammals. We
also discuss how it could be regulated in normal development and misregulated in disease. …
also discuss how it could be regulated in normal development and misregulated in disease. …
[HTML][HTML] Dynamics of DNA methylation and its functions in plant growth and development
S Kumar, T Mohapatra - Frontiers in Plant Science, 2021 - frontiersin.org
… regulation of growth, development, … dynamics of DNA methylation (cytosine/adenine) in
plants, its functions in regulating gene expression under abiotic/biotic stresses, developmental …
plants, its functions in regulating gene expression under abiotic/biotic stresses, developmental …
Active turnover of DNA methylation during cell fate decisions
… In the current Perspective, we discuss recent findings that describe this intriguing phenomenon
and the potential importance of this process during early mammalian development and …
and the potential importance of this process during early mammalian development and …
Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development
KT Falcon, KEN Watt, S Dash, R Zhao… - Proceedings of the …, 2022 - National Acad Sciences
… Altogether, our results demonstrate a dynamic spatiotemporal requirement for rRNA
transcription during mammalian cranial NCC development and corresponding tissue-specific …
transcription during mammalian cranial NCC development and corresponding tissue-specific …
[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics
… DNA methylation plays a vital role in epigenetic regulation in both plants and animals,
and typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …
and typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development
R Yan, X Cheng, C Gu, Y Xu, X Long, J Zhai, F Sun… - Nature Genetics, 2023 - nature.com
… to aberrant DNA demethylation at developmental essential genes such as Lefty1/2, which
resulted in inactivation of Lefty expression 32 . We thus examined the DNA methylation level at …
resulted in inactivation of Lefty expression 32 . We thus examined the DNA methylation level at …