The ubiquitin proteasome system and schizophrenia

S Luza, CM Opazo, CA Bousman, C Pantelis… - The Lancet …, 2020 - thelancet.com
… for neurodevelopmental disorders, such as schizophrenia. Here, we review the components
of the ubiquitin-proteasome system that are reported to be dysregulated in schizophrenia, …

Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects

MR Scott, JH Meador-Woodruff - Molecular psychiatry, 2020 - nature.com
… The underlying mechanism driving these changes remains unknown, though altered expression
of ubiquitin proteasome system (UPS) components have implicated protein degradation…

… –proteasome system, lipid metabolism and DNA damage repair are triggered by antipsychotic medication in human oligodendrocytes: implications in schizophrenia

G Seabra, V de Almeida, G Reis-de-Oliveira, F Crunfli… - Scientific reports, 2020 - nature.com
… Studies have associated the development and establishment of schizophrenia with
dysfunctions in neurotransmitter systems and oligodendrocytes 15,16 . Oligodendrocytes are cells …

Neurodevelopmental disorders (NDD) caused by genomic alterations of the ubiquitin-proteasome system (UPS): the possible contribution of immune dysregulation to …

F Ebstein, S Küry, JJ Papendorf… - Frontiers in Molecular …, 2021 - frontiersin.org
… Importantly, both ubiquitin and ubiquitin-like modifications are reversible processes which
can be counteracted anytime by ubiquitin hydrolases (also called deubiquitinating enzymes, …

[PDF][PDF] Differing Levels of Ubiquitinated Proteins and Gene Expression in the Prefrontal Cortex in Schizophrenia and Bipolar Disorder

C Hsu, L Shao, CL Beasley - bcchr.ca
… of schizophrenia (SCZ) and bipolar disorder (BD) are not yet understood. The ubiquitin-proteasome
system (… Proteins are tagged for degradation with with single ubiquitin molecules or …

Remodeling without destruction: non-proteolytic ubiquitin chains in neural function and brain disorders

A Zajicek, WD Yao - Molecular psychiatry, 2021 - nature.com
Schizophrenia Schizophrenia is a severe mental illness that affects ~1% of the population
… is characterized by episodic positive symptoms (delusions, hallucinations, paranoia, and …

Comprehensive gene expression analysis detects global reduction of proteasome subunits in schizophrenia

L Hertzberg, N Maggio, I Muler, A Yitzhaky… - Schizophrenia …, 2021 - academic.oup.com
schizophrenia. We hypothesize that the down-regulation of proteasome subunits leads to
proteasome dysfunction … Recently, the ubiquitin proteasome system (UPS), governing protein …

Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies

D Kumar, RK Ambasta, P Kumar - Ageing Research Reviews, 2020 - Elsevier
… small ubiquitin-like modifier 1 … activation, neuro inflammation, and proteasomal dysfunction.
Ubiquitin proteasome system (UPS) dysfunction is central to all the neurodegeneration …

A perspective on the potential involvement of impaired proteostasis in neuropsychiatric disorders

KK Hui, R Endo, A Sawa, M Tanaka - Biological psychiatry, 2022 - Elsevier
… pathways such as autophagy and the ubiquitin proteasomal system (UPS) can be used for …
microtubular dynamics (57) and resulted in schizophrenia-like behavioral deficits when it was …

Ubiquitin and ubiquitin-like proteins in the critical equilibrium between synapse physiology and intellectual disability

A Folci, F Mirabella, M Fossati - eneuro, 2020 - eneuro.org
… and psychiatric disorders, such as autism, ID, and schizophrenia. Since … ubiquitin
proteasome system (UPS) is the best characterized function of ubiquitination and K48 poly-ubiquitin