… for neurodevelopmental disorders, such as schizophrenia. Here, we review the components
of the ubiquitin-proteasome system that are reported to be dysregulated in schizophrenia, …

… The underlying mechanism driving these changes remains unknown, though altered expression
of ubiquitin proteasome system (UPS) components have implicated protein degradation…

… Studies have associated the development and establishment of schizophrenia with
dysfunctions in neurotransmitter systems and oligodendrocytes 15,16 . Oligodendrocytes are cells …

… Importantly, both ubiquitin and ubiquitin-like modifications are reversible processes which
can be counteracted anytime by ubiquitin hydrolases (also called deubiquitinating enzymes, …

… of schizophrenia (SCZ) and bipolar disorder (BD) are not yet understood. The ubiquitin-proteasome
system (… Proteins are tagged for degradation with with single ubiquitin molecules or …

… Schizophrenia Schizophrenia is a severe mental illness that affects ~1% of the population
… is characterized by episodic positive symptoms (delusions, hallucinations, paranoia, and …

… schizophrenia. We hypothesize that the down-regulation of proteasome subunits leads to
proteasome dysfunction … Recently, the ubiquitin proteasome system (UPS), governing protein …

… small ubiquitin-like modifier 1 … activation, neuro inflammation, and proteasomal dysfunction.
Ubiquitin proteasome system (UPS) dysfunction is central to all the neurodegeneration …

… pathways such as autophagy and the ubiquitin proteasomal system (UPS) can be used for …
microtubular dynamics (57) and resulted in schizophrenia-like behavioral deficits when it was …

… and psychiatric disorders, such as autism, ID, and schizophrenia. Since … ubiquitin
proteasome system (UPS) is the best characterized function of ubiquitination and K48 poly-ubiquitin …