The ubiquitin proteasome system and schizophrenia
… for neurodevelopmental disorders, such as schizophrenia. Here, we review the components
of the ubiquitin-proteasome system that are reported to be dysregulated in schizophrenia, …
of the ubiquitin-proteasome system that are reported to be dysregulated in schizophrenia, …
Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects
MR Scott, JH Meador-Woodruff - Molecular psychiatry, 2020 - nature.com
… The underlying mechanism driving these changes remains unknown, though altered expression
of ubiquitin proteasome system (UPS) components have implicated protein degradation…
of ubiquitin proteasome system (UPS) components have implicated protein degradation…
… –proteasome system, lipid metabolism and DNA damage repair are triggered by antipsychotic medication in human oligodendrocytes: implications in schizophrenia
… Studies have associated the development and establishment of schizophrenia with
dysfunctions in neurotransmitter systems and oligodendrocytes 15,16 . Oligodendrocytes are cells …
dysfunctions in neurotransmitter systems and oligodendrocytes 15,16 . Oligodendrocytes are cells …
Neurodevelopmental disorders (NDD) caused by genomic alterations of the ubiquitin-proteasome system (UPS): the possible contribution of immune dysregulation to …
… Importantly, both ubiquitin and ubiquitin-like modifications are reversible processes which
can be counteracted anytime by ubiquitin hydrolases (also called deubiquitinating enzymes, …
can be counteracted anytime by ubiquitin hydrolases (also called deubiquitinating enzymes, …
[PDF][PDF] Differing Levels of Ubiquitinated Proteins and Gene Expression in the Prefrontal Cortex in Schizophrenia and Bipolar Disorder
C Hsu, L Shao, CL Beasley - bcchr.ca
… of schizophrenia (SCZ) and bipolar disorder (BD) are not yet understood. The ubiquitin-proteasome
system (… Proteins are tagged for degradation with with single ubiquitin molecules or …
system (… Proteins are tagged for degradation with with single ubiquitin molecules or …
Remodeling without destruction: non-proteolytic ubiquitin chains in neural function and brain disorders
A Zajicek, WD Yao - Molecular psychiatry, 2021 - nature.com
… Schizophrenia Schizophrenia is a severe mental illness that affects ~1% of the population
… is characterized by episodic positive symptoms (delusions, hallucinations, paranoia, and …
… is characterized by episodic positive symptoms (delusions, hallucinations, paranoia, and …
Comprehensive gene expression analysis detects global reduction of proteasome subunits in schizophrenia
L Hertzberg, N Maggio, I Muler, A Yitzhaky… - Schizophrenia …, 2021 - academic.oup.com
… schizophrenia. We hypothesize that the down-regulation of proteasome subunits leads to
proteasome dysfunction … Recently, the ubiquitin proteasome system (UPS), governing protein …
proteasome dysfunction … Recently, the ubiquitin proteasome system (UPS), governing protein …
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies
… small ubiquitin-like modifier 1 … activation, neuro inflammation, and proteasomal dysfunction.
Ubiquitin proteasome system (UPS) dysfunction is central to all the neurodegeneration …
Ubiquitin proteasome system (UPS) dysfunction is central to all the neurodegeneration …
A perspective on the potential involvement of impaired proteostasis in neuropsychiatric disorders
KK Hui, R Endo, A Sawa, M Tanaka - Biological psychiatry, 2022 - Elsevier
… pathways such as autophagy and the ubiquitin proteasomal system (UPS) can be used for …
microtubular dynamics (57) and resulted in schizophrenia-like behavioral deficits when it was …
microtubular dynamics (57) and resulted in schizophrenia-like behavioral deficits when it was …
Ubiquitin and ubiquitin-like proteins in the critical equilibrium between synapse physiology and intellectual disability
A Folci, F Mirabella, M Fossati - eneuro, 2020 - eneuro.org
… and psychiatric disorders, such as autism, ID, and schizophrenia. Since … ubiquitin
proteasome system (UPS) is the best characterized function of ubiquitination and K48 poly-ubiquitin …
proteasome system (UPS) is the best characterized function of ubiquitination and K48 poly-ubiquitin …