… circadian rhythm pathway and expression of core clock gene cryptochrome 2 (CRY2) are
dysregulated in human … We reported that NR1D1 and BMAL1 mRNA and protein levels were …

… It has been reported that a 24-h diurnal rhythm is crucial in … rhythmic genes Bmal1 through
the NFKB signaling pathway [… of Per2 and Nr1d1, thus causing a decrease of Bmal1 in turn [46]…

… of life, the factors affecting osteoarthritis (OA) are not limited to … transfecting with siBMAL1
and suppressing β-catenin pathway. (A) … between BMAL1 and Wnt/β-catenin signaling pathway …

… The suppressed expression of NR1D2 mRNA after DMM procedures was significantly … of
NR1D1, the present study did not explore NR1D1 further. The transcription level of BMAL-1 was …

… circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate
osteoarthritis (OA… The expression changes of clock proteins BMAL1, NR1D1, PER3, and CRY1 in …

… also known as NR1D1) and RORA modulate Bmal1 expression by … Green positive signs
signify pathways promoting BMAL1 … Clock expression was suppressed in cartilage explants from …

… showed the largest degree of suppression in OA cartilage. … function of NR1D1 in regulation
of the circadian rhythm, which … , including Nr1d1 and Bmal1 as circadian rhythm-related genes…

… Total Bmal1 knockout leads to complete loss of circadian clock cycling. However, … of NR1D1
in normal chondrocytes resulted in altered expression of components of the TGF-β pathway […

… Circadian rhythm acts an important role in life activities. … expression of NR1D1 and BMAL1
in the knee cartilage of osteoarthritis (… of Bmal1 in condylar chondrocytes suppressed the ERK …

… and tissue homeostasis and promotes osteoarthritis (OA) … NR1D1, core clock circadian
genes that are dysregulated in … core clock genes (ie, BMAL1, CRY1, RORC, RORA, NR1D1, …