… A low concentration leads to a reduction in ligand density and cell–ECM … by endothelial
integrin receptors interacting with ECM proteins and mediating focal adhesion, again regulating …

… change and promote their binding with permissive ligands. Disturbed flow activates … The
interaction between ECM and endothelial integrin receptors becomes a favorable therapeutic …

… vascular ECM proteins and the main binding sites for integrins, … ligands, as well as crosstalk
with other endothelial integrins, as … Importantly, pathways regulating angiogenesis may vary …

… The expression of different integrins on SMC, their ECM ligand, and their possible role in …
EDA (Fn-EDA) in the ECM is synthesized by vascular cells, including endothelial cells, and its …

… Already in the bent conformation, integrins are capable of binding ECM ligands with low …
to be overexpressed on angiogenic endothelial cells in concert with numerous pro- and anti-…

… to growth factors, and (iii) endothelial integrins. While sensing the proangiogenic directional
cues … remodeling of ECM promotes novel integrin–ligand interactions (loss of α1β1 integrin …

… ECM can be engineered with specific signaling molecules or ligands to elicit an angiogenic
… sprouts suggesting that fibrils are pulled through integrin binding (Figure 1a) as endothelial …

… state include integrin and nonintegrin ECM receptors, which … membrane components
underlying the endothelial cells (ECs… toll-like receptor ligands, including lipopolysaccharide, that …

… such as selectins and integrins enables endothelial cells to … In addition to their role in
angiogenesis and ECM remodeling… interact with the monocytes via P-selectin glycoprotein …

… Ligation of integrins to ECM ligands initiate intracellular signaling through so-called outside-…
that endothelial cell integrin activation is requisite for retinal and pathological angiogenesis. …