… , including NF-κB, MAPK, mTOR, JAK/STAT and c-Myc [23, 24]… to the activation of Epidermal
growth factor receptor (EGFR). … EFEMP1 was a secreted matricellular glycoprotein with five …

… examined whether EFEMP1 could target STEAP1 to activate TGF… as a positive regulator of
the AKT signal pathway [24]. … , EFEMP1 binds to epidermal growth factor receptor (EGFR) and …

… Several pathways have been postulated to underlie these … in pancreatic cancer cells and
later shown in other solid tumors … reduced PI3K/Akt as well as MAPK activation, whereas fibulin-…

… of EGF and activates MAPK/ERK, PI3K/Akt/mTOR, and other … The epidermal growth factor
receptor (EGFR) family has … and invasion of trophoblast cells by targeting EFEMP1/Akt (26). …

… In pancreatic cancer, EFEMP1 binds to the EGF receptor and activates the Akt and MAPK
pathways that enhance tumor … However, the neoplastic roles of EFEMP1 in UTUC and UBUC …

… pathway, p53 signaling pathway, MAPK signaling pathway, protein … in cancer, focal adhesion,
Rap1 signaling pathway, PI3K-Akt … Changes in EFEMP1 expression have previously been …

… the translation of epidermal growth factor receptor (EGFR)/EFEMP1 (EGF-… EFEMP1 enhanced
pancreatic carcinoma cell growth by binding to EGFR to activate MAPK and Akt pathways…

… of the PI3K/AKT pathway in primary SFs following EFEMP1 … EFEMP1's role is further
accentuated as a binding ligand for … EFEMP1 protein interacts with the EGFR receptor, instigating …

… in the crucial pathways of ECM synthesis and remodelling. However, since only EFEMP1 …
stroma acquires an aggressive phenotype [28]; however, how such activation occurs is still …

… epidermal growth factor receptor (EGFR) signaling pathway … for PI3K-Akt pathway activation
and survival in NSCLC cells (48… for MAPK pathway and RTK signaling activation. In baseline …