… of improperly managed DNA single-strand breaks. Furthermore, … DNA end resection is a
process by which one of the DNA … EXOSC10 is required for efficient DNA repair, and the RPA …

… DNA end resection has a key role in double-strand break … Thus, RAD50 acts as a molecular
switch for controlling MRE11 … RPA complex in the regulation of DNA end resection extension. …

… -dependent control of RNAPII function, we depleted EXOSC10 … required to prevent activation
of the ATM kinase in MYCN-driven tumor cells. To determine whether double-strand breaks …

… effects of DNA:RNA hybrid presence on DNA end resection … The presence of such structures
might block RPA loading. … DSB repair, controlling the licensing of DNA end resection, thus …

… DNA end resection [111]. Moreover, EXOSC10, an RNA exosome subunit, processes
RNA:DNA … controlled in order to preserve genome integrity. Data suggest that the role of RNA:…

… Nevertheless, we managed to sequence smaller fusion products (deletions) and confirmed
… strand annealing and RPA phosphorylation-induced DNA damage checkpoint activation. …

… that expression of Exosc10 is crucial for controlling cell survival and cortical development.
Our findings indicate that Exosc10 performs an essential function in controlling P53-mediated …

… used the RNWG control reporter, in which the stop codon is pre-… , a core DNA end resection
factor that is also required for ATR … To test this idea, we first studied RPA foci formation upon …

… EXOSC10 mediated accumulation of dilncRNAs and RNA:DNA hybrids, accompanied by
increased DNA end resection … Within seconds after induction of a single- or double-strand break…

… milieu and control various cellular … DNA end resection are restored by transcription inhibitors,
and RNase H1 overexpression restores the RPA recruitment defect caused by EXOSC10 …