Discovery of RC-752, a Novel Sigma-1 receptor antagonist with antinociceptive activity: a promising tool for fighting neuropathic pain

G Rossino, A Marra, R Listro, M Peviani, E Poggio… - Pharmaceuticals, 2023 - mdpi.com
… the swim bladder was not well inflated, and oedema was evident. … related to a potentially
recoverable developmental delay or … The formalin test was chosen as a tonic pain model for the …

Delta-and mu-opioid pathways are involved in the analgesic effect of Ocimum basilicum L in mice

AH Bae, G Kim, GH Seol, SB Lee, JM Lee… - Journal of …, 2020 - Elsevier
… The solvent delay time of mass spectrometer was 3 min with m/… that BEO reduced
carrageenan-induced edema and pyrexia … Antinociceptive activities of the methanol extract of the …

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

R Turnaturi, S Piana, S Spoto, G Costanzo, L Reina… - Molecules, 2024 - mdpi.com
formalin test, SLE and fruticuline A significantly reduced the frequency of paw licking during
the first and second phases and decreased edemabut delayed, effect in the hot-plate test. …

[PDF][PDF] Antinociceptive and antiinflammatory studies on Tradescantia zebrina

N Baghalpour, SA Ayatollahi, N Naderi… - Pak. J. Bot, 2021 - pakbs.org
… compromise the immune system, cause infections, and delay the diagnosis and treatment of
… of the formalin test.Based on our results from the carrageenan-induced paw edema test, the …

Acidosis-related pain and its receptors as targets for chronic pain

CH Hung, Y Chin, YO Fong, CH Lee, DS Han… - Pharmacology & …, 2023 - Elsevier
pain research and clinical pain diseases, thus helping with better understanding the acid-related
pain … potential therapeutic roles via the mechanism of acid-mediated antinociception. …

Venlafaxine HCl encapsulated in niosome: green and eco-friendly formulation for the management of pain

SMH Hashemi, R Enayatifard, J Akbari, M Saeedi… - AAPS …, 2022 - Springer
… The delay time for reactions to pain stimulation was then … -inflammatory and antinociceptive
action in the formalin test (22)… of 0.333 for edema and erythema which was much smaller than …

[HTML][HTML] Chemical composition, antioxidant, anti-inflammatory and antinociceptive activities of the ethanol extract of ripe fruits of Solanum lycocarpum St. Hil …

MG Morais, AA Saldanha, JPC Rodrigues… - Journal of …, 2020 - Elsevier
Pain involves mechanisms related to the response of the … effect observed in the first phase
of the formalin test. … potential, provoking the reduction of ear edema induced by chroton oil and …

Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea

…, RG Thomé, HB Dos Santos, DO Lopes… - …, 2021 - Springer
… Moreover, the in vivo antinociceptive effect was assayed using the formalin test and …
Treatment with the EFDf also resulted in significant paw oedema reduction in the … Full size image …

Micro-and nanocarriers for pain alleviation

A da Silva, S Lepetre-Mouelhi, P Couvreur - Advanced Drug Delivery …, 2022 - Elsevier
… inflammation levels is highly correlated to pain intensity, publications … of NPs in the dorsal
root ganglion, Prolonged antinociception … ) / Measurement of the paw edema thickness In vivo …

Anti-inflammatory activity of Cleome ciliata leaf Schumach & Thonn. in acute and chronic inflammatory models using rodents

I Igbe, O Oghosa, O Edosuyi - Igbinedion University Okada Journal of …, 2023 - ajol.info
… effect against formalin-induced arthritis, reducing paw size at … further observed for signs of
delayed toxicity after two weeks [14]. … dextran-induced paw oedema is principally mediated by …