Biphalin—A Potent Opioid Agonist—As a Panacea for Opioid System-Dependent Pathophysiological Diseases?

P Redkiewicz, J Dyniewicz, A Misicka - International Journal of Molecular …, 2021 - mdpi.com
… Extensive research on its antinociceptive effect has shown its … and jumping was delayed in
the hot plate test in comparison … that the reduction in neuronal cellular edema is caused by the …

Cedrus atlantica (Endl.) Manetti ex Carrière Essential Oil Alleviates Pain and Inflammation with No Toxicity in Rodent

O Al Kamaly, A Saleh, A Al Sfouk, AS Alanazi… - Processes, 2022 - mdpi.com
… -induced paw edema and formalin tests) and analgesic … The dependent variable is usually
the delay of the animal’s … An antinociceptive or analgesic response is defined as a substantial …

[HTML][HTML] Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog

M Chartier, M Desgagné, M Sousbie, C Rumsby… - Biomedicine & …, 2021 - Elsevier
… , as the antinociceptive effects of NT are mediated by activation of the … using the formalin
test as a model of persistent pain. Before … swelling of the ipsilateral hind paw, accompanied by …

[HTML][HTML] Sex differences in tolerance to delta-9-tetrahydrocannabinol in mice with cisplatin-evoked chronic neuropathic pain

AN Henderson-Redmond, LTC Crawford… - Frontiers in molecular …, 2021 - frontiersin.org
… tolerance and increased sensitivity to the antinociceptive … study was to determine whether
tolerance was also delayed … in pain according to a numerical rating scale for pain intensity (…

Cordia oncocalyx and oncocalyxones: From the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases

PMP Ferreira, AAC de Almeida, MLP Conceição… - Fitoterapia, 2023 - Elsevier
… Such fraction reduced carrageenaninduced edema formation … , which, in turns, hamper/delay
the formation of intracellular … antinociceptive actions of ellagic acid in the rat formalin test, …

NAAA-regulated lipid signaling governs the transition from acute to chronic pain

Y Fotio, KM Jung, F Palese, A Obenaus, AM Tagne… - Science …, 2021 - science.org
… (D) Lack of correlation between formalin-induced paw edema (Δ … distinguishable from their
antinociceptive and anti-… period stops CPLS development but does not affect the size of the …

Fentanyl but not morphine or buprenorphine improves the severity of necrotizing acute pancreatitis in rats

ER Bálint, G Fűr, B Kui, Z Balla, ES Kormányos… - International Journal of …, 2022 - mdpi.com
… Fentanyl did not affect the outcome of edematous AP. … MO application delayed AP resolution
and reduced intestinal … The third part of the pancreas was fixed in 8% neutral formaldehyde

The ameliorative effect of thymoquinone on vincristine-induced peripheral neuropathy in mice by modulating cellular oxidative stress and cytokine

SK Alenezi - Life, 2022 - mdpi.com
… Pregabalin treatment reduced neuropathic pain in rats after chronic constriction injury [44]. …
antinociceptive effects of TQ in the hotplate, cold plate, and delayed phase of the formalin test

Anti-Inflammatory and Analgesic Activity of Methanolic Root Extract of Verbascum sinaiticum Benth

M Asefa, N Teshome, A Degu - Journal of Inflammation Research, 2022 - Taylor & Francis
… of antinociceptive maximal possible effect (MPE) was calculated … The same pattern with
delayed pain reaction time was also … In terms of paw edema reduction and percentage edema

Anti-inflammatory, analgesic, and antipyretic potential of Oxystelma esculentum (L. f.) Sm. using in vitro, in vivo, and in silico studies

AE Sherif, M Sajid-ur-Rehman, M Asif… - Frontiers in …, 2024 - frontiersin.org
was determined by the carrageenan-induced paw edema … required to evaluate the anti-inflammatory
and antinociceptive … In the tail immersion test, there was an increase in delay time …