… for CFTR is its negative regulation of the amiloridesensitive epithelial Na+ channel (ENaC). …
), and associated clearance mode available in such devices, integrate a cough assistance …

… These repeated cycles leads to the permanent dilation of the bronchi known as bronchiectasis
leading to chronic cough, sputum production, recurrent respiratory infection, and acute …

… IPF patient-derived versus healthy lung-derived fibroblasts showed AQP1 induction in
response to TGF-β treatment in the former, implying AQP1 role in the pro-fibrotic TGF-β action and …

… to its effect on coughing and development of associated co-morbid conditions [9]. Coughing
… Some research teams are focusing on the effect of amiloride, an antagonist of ENaCs. One …

… These studies compared the delivery of tobramycin, colistin, dornase alfa, hypertonic saline
and … The most common adverse events were upper respiratory infection, cough, and nasal …

… Mechanism of Action Protects the myocardium from toxic effects of potassium; no effect on
total body potassium Shifts potassium intracellularly: no effect on total body potassium Shifts …

… Induced sputum (IS) using nebulised hypertonic saline (HTS) … surface hydration and
mucociliary clearance suggests a … 11%(2) reported a mild AE during the DRA (cough) but were …

… = The amiloridesensitive epithelial … cough or difficulty in expectorating sputum is a clinical
symptom that reflects the presence of an impaired mucociliary clearance system in people …

… function with patients that have nasal polysis and chronic … by which hypertonic solution
improves mucociliary clearance, … TPB (1997) Effect of increasing doses of hypertonic saline on …

… mucociliary clearance and host-mediated antimicrobials create opportunities for microbial
… and hypertonic saline, which increases mucociliary clearance, result in positive impacts on …