… of novel pharmacotherapies for Methamphetamine Use Disorder based on the selective
modulation mGlu … explored using mGlu5 positive allosteric modulators (PAMs); see below. …

… after day 6 of AZD8529 treatment, suggesting that the beneficial effect of reducing drug
self-administration may outlast some off-target effects on other consummatory behaviors (Li et al., …

… Positive allosteric modulators (PAMs) of mGlu 2 and negative allosteric modulators of mGlu
5 … behaviors represents an important strategy for identifying novel therapeutic mechanisms. …

… In this review, we discuss what is currently known regarding the contribution of mGluR2 and
… the allosteric site, they can either enhance glutamate response (positive allosteric modulator…

… negative allosteric modulators show acute antidepressant-like … of novel mGlu 2 and mGlu
3 negative allosteric modulators. … In the schizophrenia trials, AZD8529 did not affect primary …

… This review focuses on causal studies on incubation of methamphetamine craving. … Positive
allosteric modulator Ligands that bind to an allosteric binding site on a receptor, resulting in …

… receptor positive allosteric modulator (PAM), AZD8529, … with methamphetamine (5 μM) 10
min after the incubation with … into novel therapeutic options for methamphetamine addiction. …

… mechanism of action of the atypical DAT inhibitors might provide novel … positive allosteric
modulator of mGluR2, AZD8529, has been shown to decrease incubation of methamphetamine …

… investigated as a target for novel medications for cocaine use … cocaine and/or
methamphetamine in the context of a food-drug … pharmacotherapies, positive allosteric modulators …

… ‘Positive allosteric modulation of mGluR5 receptors facilitates extinction of a … AZD8529 (a
new and hilghly selective mGluR2 PAM), which can decrease cue-induced methamphetamine …